The effect of luteal-phase support with vaginal progesterone on pregnancy rates in gonadotropin and clomiphene citrate/intra-uterine insemination cycles in unexplained infertility: A prospective randomised study

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dc.contributor.authorKaradag, Burak
dc.contributor.authorDilbaz, Berna
dc.contributor.authorKarcaaltincaba, Deniz
dc.contributor.authorSahin, Elif Gulsah
dc.contributor.authorErcan, Fedi
dc.contributor.authorKarasu, Yetkin
dc.contributor.authorTonyali, Nazan Vanli
dc.date.accessioned2024-02-23T14:34:36Z
dc.date.available2024-02-23T14:34:36Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractThe purpose of this study is to analyse the effect of luteal-phase support on pregnancy rates in gonadotropin+intra-uterine insemination (Gn/IUI) and clomiphene citrate (CC)+IUI (CC/IUI) cycles in patients with unexplained infertility. Equal numbers of patients were recruited in two treatment arms (CC/IUI and Gn/IUI) (n=100, n=100, respectively). In each group, 50 patients received vaginal progesterone for 14 days (Crinone 8% vaginal gel, 90mg per day) for luteal-phase support from the day after IUI and continued until menstruation or the 10th week of gestation if pregnant. There were 29 clinical pregnancies among 200 patients. Pregnancy rates were 12% in CC/IUI cycles, 10% in luteal-phase-supported CC/IUI cycles 16% in Gn/IUI cycles and 20% in luteal-phase-supported Gn/IUI cycles. Although pregnancy rates were higher in Gn/IUI cycles compared to CC/IUI cycles, luteal-phase support did not significantly affect the pregnancy rates in both groups. This study implies that luteal-phase support with progesterone has no pronounced beneficial effect on pregnancy rates in either CC/IUI or Gn/IUI cycles in patients with unexplained infertility.en_US
dc.identifier.doi10.3109/01443615.2016.1154511
dc.identifier.endpage799en_US
dc.identifier.issn0144-3615
dc.identifier.issn1364-6893
dc.identifier.issue6en_US
dc.identifier.pmid27146108en_US
dc.identifier.scopus2-s2.0-84965000347en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage794en_US
dc.identifier.urihttps://doi.org/10.3109/01443615.2016.1154511
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15650
dc.identifier.volume36en_US
dc.identifier.wosWOS:000388489600022en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal Of Obstetrics And Gynaecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectUnexplained Infertilityen_US
dc.subjectOvulation Inductionen_US
dc.subjectLuteal-Phase Supporten_US
dc.subjectPregnancy Rateen_US
dc.titleThe effect of luteal-phase support with vaginal progesterone on pregnancy rates in gonadotropin and clomiphene citrate/intra-uterine insemination cycles in unexplained infertility: A prospective randomised studyen_US
dc.typeArticleen_US

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