Effect of sumac extract on serum oxidative status, RANKL/OPG system and alveolar bone loss in experimental periodontitis in rats
dc.contributor.author | Saglam, Mehmet | |
dc.contributor.author | Koseoglu, Serhat | |
dc.contributor.author | Hatipoglu, Mukerrem | |
dc.contributor.author | Esen, Haci Hasan | |
dc.contributor.author | Koksal, Ekrem | |
dc.date.accessioned | 2024-02-23T14:30:08Z | |
dc.date.available | 2024-02-23T14:30:08Z | |
dc.date.issued | 2015 | |
dc.department | NEÜ | en_US |
dc.description.abstract | Objectives: Sumac (Rhus coriaria L.) is widely used spice which has several properties such as antioxidant, anti-inflammatory and antimicrobial. The purpose of this animal study was to evaluate the effects of sumac extract on levels of receptor activator of nuclear factor-kappa B ligand (RANKL), osteoprotegerin (OPG) expression, serum oxidative status, and alveolar bone loss in experimental periodontitis. Material and Methods: Twenty-four Wistar rats were separated into three groups: non-ligated (NL, n=8), ligature only (LO, n=8), and ligature and treated with sumac extract (S, n=8) (20 mg/kg per day for 11 days). A 4/0 silk suture was placed around the mandibular right first molars subgingivally; after 11 days, the rats were sacrificed, and alveolar bone loss was histometrically measured. The detection of RANKL and OPG were immunohistochemically performed. Levels of serum total antioxidant status (TAS)/total oxidant status (TOS), and oxidative stress index (OSI) were also analyzed. Results: Alveolar bone loss was significantly greater in the LO group compared to the S and NL groups (p<0.05). The number of inflammatory cell infiltrate (ICI) and osteoclasts in the LO group was significantly higher than that of the NL and S groups (p<0.05). The number of osteoblasts in the LO and S groups was significantly higher than that of the NL group (p<0.05). There were significantly more RANKL-positive cells in the LO group than in the S and NL groups (p<0.05). OPG-positive cells were higher in S group than in LO and NL groups (p<0.05). TOS and OSI levels were significantly reduced in S group compared to LO group (P<0.05) and TAS levels were similar in S and NL group (p>0.05). Conclusions: The present study showed that systemic administration of sumac extract may reduce alveolar bone loss by affecting RANKL/OPG balance, TOS and OSI levels in periodontal disease in rats. | en_US |
dc.identifier.doi | 10.1590/1678-775720140288 | |
dc.identifier.endpage | 41 | en_US |
dc.identifier.issn | 1678-7757 | |
dc.identifier.issn | 1678-7765 | |
dc.identifier.issue | 1 | en_US |
dc.identifier.pmid | 25760266 | en_US |
dc.identifier.scopus | 2-s2.0-84924455974 | en_US |
dc.identifier.scopusquality | Q1 | en_US |
dc.identifier.startpage | 33 | en_US |
dc.identifier.uri | https://doi.org/10.1590/1678-775720140288 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12452/15031 | |
dc.identifier.volume | 23 | en_US |
dc.identifier.wos | WOS:000351541300007 | en_US |
dc.identifier.wosquality | Q3 | en_US |
dc.indekslendigikaynak | Web of Science | en_US |
dc.indekslendigikaynak | Scopus | en_US |
dc.indekslendigikaynak | PubMed | en_US |
dc.language.iso | en | en_US |
dc.publisher | Univ Sao Paulo Fac Odontologia Bauru | en_US |
dc.relation.ispartof | Journal Of Applied Oral Science | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Rhus | en_US |
dc.subject | Alveolar Bone Loss | en_US |
dc.subject | Periodontal Diseases | en_US |
dc.subject | Receptor Activator Of Nuclear Factor-Kappa B Ligand | en_US |
dc.subject | Osteoprotegerin | en_US |
dc.title | Effect of sumac extract on serum oxidative status, RANKL/OPG system and alveolar bone loss in experimental periodontitis in rats | en_US |
dc.type | Article | en_US |