The effect of melatonin and vitamin C treatment on the experimentally induced tympanosclerosis: study in rats

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dc.contributor.authorKoc, Sema
dc.contributor.authorKiyici, Halil
dc.contributor.authorToker, Aysun
dc.contributor.authorSoyalic, Harun
dc.contributor.authorAslan, Huseyin
dc.contributor.authorKesici, Hakan
dc.contributor.authorKaraca, Zafer I.
dc.date.accessioned2024-02-23T14:02:21Z
dc.date.available2024-02-23T14:02:21Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractIntroduction: The ethiopathogenesis of tympanosclerosis has not been completely under-stood yet. Recent studies have shown that free oxygen radicals are important in the formation of tympanosclerosis. Melatonin and Vitamin C are known to be a powerful antioxidant, interacts directly with Reactive Oxygen Species and controls free radical-mediated tissue damage. Objective: To demonstrate the possible preventative effects of melatonin and Vitamin C on tympanosclerosis in rats by using histopathology and determination of total antioxidant status total antioxidant status. Methods: Standard myringotomy and standard injury were performed in the middle ear of 24 rats. The animals were divided into three groups: Group 1 received melatonin, Group 2 received vitamin C, and Group 3 received saline solution. Results: The mean values of total antioxidant status were similar in the all study groups before the treatment period. The mean values of total antioxidant status were significantly higher in the melatonin and vitamin C groups compared to control group but vitamin C with melatonin groups were similar after the treatment period (p < 0.001). Minimum and maximum wall thicknesses were lower in the melatonin and vitamin C groups compared to the control group but the differences were insignificant. Conclusion: Melatonin increases total antioxidant status level and might have some effect on tympanosclerosis that develops after myringotomy. (C) 2016 Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial. Published by Elsevier Editora Ltda.en_US
dc.identifier.doi10.1016/j.bjorl.2016.06.008
dc.identifier.endpage545en_US
dc.identifier.issn1808-8694
dc.identifier.issn1808-8686
dc.identifier.issue5en_US
dc.identifier.pmid27484331en_US
dc.identifier.scopus2-s2.0-84997821052en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage541en_US
dc.identifier.urihttps://doi.org/10.1016/j.bjorl.2016.06.008
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11664
dc.identifier.volume83en_US
dc.identifier.wosWOS:000412366300008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAssoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacialen_US
dc.relation.ispartofBrazilian Journal Of Otorhinolaryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTympanosclerosisen_US
dc.subjectMelatoninen_US
dc.subjectVitamin Cen_US
dc.subjectTotal Antioxidant Statusen_US
dc.titleThe effect of melatonin and vitamin C treatment on the experimentally induced tympanosclerosis: study in ratsen_US
dc.typeArticleen_US

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