Is there a relationship between cardiovascular risk factors and dehydroepiandrosterone sulfate levels in childhood obesity?

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dc.contributor.authorAkyurek, Nesibe
dc.contributor.authorAtabek, Mehmet Emre
dc.contributor.authorEklioglu, Beray Selver
dc.contributor.authorAlp, Hayrullah
dc.date.accessioned2024-02-23T14:31:52Z
dc.date.available2024-02-23T14:31:52Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractAim: In this study, parameters of metabolic syndrome and dehydroepiandrosterone sulfate (DHEAS) levels in obese children and adolescents were evaluated and the associations between these factors were analyzed. Method: One hundred obese and 40 healthy children/ adolescents were included in the study. Pubertal stages, anthropometric and blood pressure measurements were recorded. Levels of fasting serum lipids, glucose, insulin, and DHEAS, and liver function tests were determined. Carotid intima-media thickness (CIMT) was measured using two-dimensional echocardiography. Steatorrhoeic hepatosis was evaluated using abdominal ultrasonography in the obese group. Results: Mean body weight, body mass index, waist, hip circumference, waist/hip ratio, homeostatic model assessment of insulin resistance, triglycerides, high-density lipoprotein cholesterol, alanine transferase, DHEAS, and CIMT values were significantly higher in the obese group than in the controls. DHEAS levels were found to be positively correlated with waist circumference, waist/hip ratio, and CIMT. Conclusion: Early determination of metabolic and cardiac dysfunction in obese children is important for the prevention of future complications. Since in this study we found a strong association between DHEAS levels and obesity-related metabolic and cardiovascular risk factors, we believe that this may lead to increased interest in further studies of DHEAS in the search for new treatment approaches.en_US
dc.identifier.doi10.1515/jpem-2014-0253
dc.identifier.endpage550en_US
dc.identifier.issn0334-018X
dc.identifier.issn2191-0251
dc.identifier.issue5.Hazen_US
dc.identifier.pmid25381943en_US
dc.identifier.scopus2-s2.0-84928954559en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage545en_US
dc.identifier.urihttps://doi.org/10.1515/jpem-2014-0253
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15384
dc.identifier.volume28en_US
dc.identifier.wosWOS:000353793000009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofJournal Of Pediatric Endocrinology & Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCardiovascular Diseaseen_US
dc.subjectDehydroepiandrosterone Sulfateen_US
dc.subjectObesityen_US
dc.titleIs there a relationship between cardiovascular risk factors and dehydroepiandrosterone sulfate levels in childhood obesity?en_US
dc.typeArticleen_US

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