Histopathological comparison of pathergy positive and negative areas of newly diagnosed Behcet patients

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dc.contributor.authorTemiz, Selami Aykut
dc.contributor.authorBalevi, Sukru
dc.contributor.authorOltulu, Pembe
dc.contributor.authorOzer, Ilkay
dc.date.accessioned2024-02-23T14:24:16Z
dc.date.available2024-02-23T14:24:16Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractBackground Behcet's disease is an inflammatory vasculitis, and pathergy reaction is a compulsory element of the diagnostic criteria. In the literature, there is no study comparing the histopathology of negative pathergy tests and positive pathergy tests in newly diagnosed Behcet's patients. The primary goal was to investigate the frequency of vasculitis, which is an important finding of Behcet's disease, in pathergy histopathology. Methods The histopathology of patients with positive and negative pathergy tests revealed vasculitis or vasculopathy. In histopathology, neutrophils, lymphocytes, eosinophils, and mast cells in the perivascular area were counted and recorded as a percentage. Results Of the 88 Behcet's patients who participated in the study, 45 were female and 43 were male. The rate of vasculitis in the histopathology of those who were positive for the pathergy test was not statistically different than those of those with negative pathergy tests (P = .14). In our study, although the relationship between the male gender and uveitis was significant at the border, and the relationship between pathergy positivity and uveitis was not found to be significant, a significant relationship was found between vasculitis in histopathology and uveitis (P = .023). Conclusions Based on the results of our study, we think that a pathergy test of histopathology will contribute to the clinical diagnostic evaluation in cases with suspicious clinical pathergy tests and especially in cases with negative pathergy tests.en_US
dc.identifier.doi10.1111/ijcp.14994
dc.identifier.issn1368-5031
dc.identifier.issn1742-1241
dc.identifier.issue12en_US
dc.identifier.pmid34710265en_US
dc.identifier.scopus2-s2.0-85118475742en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1111/ijcp.14994
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13872
dc.identifier.volume75en_US
dc.identifier.wosWOS:000714881400001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Hindawien_US
dc.relation.ispartofInternational Journal Of Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[Keyword Not Available]en_US
dc.titleHistopathological comparison of pathergy positive and negative areas of newly diagnosed Behcet patientsen_US
dc.typeArticleen_US

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