Prognostic importance of neutrophil-lymphocyte ratio in critically ill patients: short- and long-term outcomes

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dc.contributor.authorAkilli, Nazire Belgin
dc.contributor.authorYortanli, Mehmet
dc.contributor.authorMutlu, Huseyin
dc.contributor.authorGunaydin, Yahya Kemal
dc.contributor.authorKoylu, Ramazan
dc.contributor.authorAkca, Hatice Seyma
dc.contributor.authorAkinci, Emine
dc.date.accessioned2024-02-23T14:00:18Z
dc.date.available2024-02-23T14:00:18Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractStudy objective: The number of critically ill patients admitted to the emergency department increases daily. To decrease mortality, interventions and treatments should be conducted in a timely manner. It has been found that the neutrophil-lymphocyte ratio (NLR) is related to mortality in some disease groups, such as acute coronary syndrome and pulmonary emboli. The effect of the NLR on mortality is unknown in critically ill patients who are admitted to the emergency department. Our aim in this study is to evaluate the effect of the NLR on mortality in critically ill patients. Methods: This study was planned as a prospective, observational cohort study. Patients who were admitted to the emergency department because they were critically ill and required the intensive care unit were included in the study. Demographic characteristics, Acute Physiology and Chronic Health Evaluation II (APACHE II), Sepsis-related Organ Failure Assessment, Glasgow Coma Score, and NLR values were recorded upon emergency department admission. The patients were followed up for sepsis, ventilator-associated pneumonia, multiorgan failure, in-hospital mortality, and 6-month mortality. Results: The median (interquartile range) age of the 373 patients was 74 (190) years, and 54.4% were men. Neutrophil-lymphocyte ratio values were divided into quartiles, as follows: less than 3.48, 3.48 to 6.73, 6.74-13.6, and more than 13.6. There was no difference among these 4 groups regarding demographic characteristics, APACHE II score, Sepsis-related Organ Failure Assessment score, Glasgow Coma Score, and length of hospital stay (P > .05). In the multivariable Cox regression model, in-hospital mortality and 6-month mortality NLR were hazard ratio (HR), 1.63 (1.110-2.415; P = .01) and HR, 1.58 (1.136-2.213; P = .007), respectively, and APACHE II scores were detected as independent indicators. Conclusion: The NLR is a simple, cheap, rapidly available, and independent indicator of short- and long-term mortalities. We suggest that the NLR can provide direction to emergency department physicians for interventions, particularly within a few hours after admission, in the critically ill patient group. (C) 2014 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.ajem.2014.09.001
dc.identifier.endpage1480en_US
dc.identifier.issn0735-6757
dc.identifier.issn1532-8171
dc.identifier.issue12en_US
dc.identifier.pmid25264245en_US
dc.identifier.scopus2-s2.0-84916940720en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1476en_US
dc.identifier.urihttps://doi.org/10.1016/j.ajem.2014.09.001
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11545
dc.identifier.volume32en_US
dc.identifier.wosWOS:000346353000007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofAmerican Journal Of Emergency Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[Keyword Not Available]en_US
dc.titlePrognostic importance of neutrophil-lymphocyte ratio in critically ill patients: short- and long-term outcomesen_US
dc.typeArticleen_US

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