Risk factors for recurrent pulmonary exacerbation in idiopathic pulmonary hemosiderosis

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dc.contributor.authorHizal, Mina
dc.contributor.authorEryilmaz Polat, Sanem
dc.contributor.authorRamasli Gursoy, Tugba
dc.contributor.authorOzsezen, Beste
dc.contributor.authorAdemhan Tural, Dilber
dc.contributor.authorKarakaya, Jale
dc.contributor.authorEmiralioglu, Nagehan
dc.date.accessioned2024-02-23T13:03:30Z
dc.date.available2024-02-23T13:03:30Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractObjectives: To evaluate the risk factors of recurrent pulmonary exacerbation and poor prognosis in children with idiopathic pulmonary hemosiderosis (IPH). Methods: In this multicenter study, 54 patients with a diagnosis of IPH were included. Medical records were retrospectively reviewed from three tertiary care hospitals between 1979 and 2019. Also, current information and the long-term progress of patients was determined by contacting the families by telephone. Results: A total of 54 children were included. The median age of onset of symptoms was 4.5 years (3 months to 15.8 years). The median time from onset to diagnosis was 0.9 years (0.25 months to 12 years). The mean number of recurrent episodes per child in the recurrence-positive group was 3.55 (1-15). Univariate analysis demonstrated that patients presenting with hypoxia or requiring transfusion at the time of presentation had significantly more recurrence episodes (p = .002). Multivariate analysis showed that the presence of hypoxia at the time of initial presentation was a significant independent predictor of recurrent episodes (p = .027). The median follow-up was 3.3 years (0.75 months to 27 years). There was a significant relationship between the presence of hypoxia, transfusion history, antinuclear antibody positivity, and elevated transaminases at the time of initial evaluation and treatment response. Conclusions: The present study provides substantial information regarding factors that may affect recurrent exacerbations and prognosis in children with IPH. Demonstrating hypoxia as an independent risk factor in recurrence episodes could guide physicians in the planning of treatment strategies.en_US
dc.identifier.doi10.1002/ppul.25189
dc.identifier.endpage1068en_US
dc.identifier.issn8755-6863
dc.identifier.issn1099-0496
dc.identifier.issue5en_US
dc.identifier.pmid33247613en_US
dc.identifier.scopus2-s2.0-85102693285en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1060en_US
dc.identifier.urihttps://doi.org/10.1002/ppul.25189
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10648
dc.identifier.volume56en_US
dc.identifier.wosWOS:000629708000001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPediatric Pulmonologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnemiaen_US
dc.subjectChildrenen_US
dc.subjectHemoptysisen_US
dc.subjectInterstitial Lung Diseaseen_US
dc.titleRisk factors for recurrent pulmonary exacerbation in idiopathic pulmonary hemosiderosisen_US
dc.typeArticleen_US

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