Detection of the frequency of PER-1 type extended-spectrum ?-lactamase-producing Acinetobacter baumannii clinical isolates in Turkey: a multicenter study

Basit Öğe Kaydı
dc.contributor.authorAsik, Gulsah
dc.contributor.authorOzdemir, Mehmet
dc.contributor.authorKurtoglu, Muhammet Guzel
dc.contributor.authorYagci, Server
dc.contributor.authorOksuz, Lutfiye
dc.contributor.authorGul, Mustafa
dc.contributor.authorKocoglu, Mucahide Esra
dc.date.accessioned2024-02-23T14:37:21Z
dc.date.available2024-02-23T14:37:21Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractBackground/aim: beta-Lactamases are an important resistance mechanism in Acinetobacter baumannii. Pseudomonas extended-resistance (PER-1) type beta-lactamase-producing strains have been reported from various geographic locations; however, PER-1 type beta-lactamases from Turkish hospitals have not been investigated extensively. The aim of this study was to determine the prevalence of PER-1 type beta-lactamases in A. baumannii isolates in various regions of Turkey. Materials and methods: A total of 763 clinical A. baumannii isolates were collected from 9 university hospitals and 2 state hospitals between 2008 and 2011. Molecular amplification of the OXA-51 gene from the A. baumannii genome was performed in order to verify identification of the species. Real-time polymerase chain reaction was used to detect bla(PER-1) genes. Results: PER-1 was detected in 24.6% of the isolates. The annual frequencies of the PER-1 enzyme were detected as 52.2%, 35.9%, and 8.3% in 2008, 2009, and 2010, respectively. PER-1 prevalence decreased gradually over time. The differences observed in PER-1 prevalence among the regions of Turkey were statistically significant (chi-square test; P < 0.001). Conclusion: These data demonstrate that the frequency of detection of PER-1 type beta-lactamases in A. baumannii species has decreased in Turkey. However, the increased carbapenem resistance, together with multidrug resistance, has created a worrisome situation regarding this pathogen.en_US
dc.identifier.doi10.3906/sag-1309-126
dc.identifier.endpage1046en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue6en_US
dc.identifier.pmid25552158en_US
dc.identifier.scopus2-s2.0-84908069063en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1041en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1309-126
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16068
dc.identifier.volume44en_US
dc.identifier.wosWOS:000344155900019en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcinetobacter Baumanniien_US
dc.subjectBeta-Lactamasesen_US
dc.subjectPer-1en_US
dc.titleDetection of the frequency of PER-1 type extended-spectrum ?-lactamase-producing Acinetobacter baumannii clinical isolates in Turkey: a multicenter studyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu