Magnetic nanoparticles embedded microcryogels for bilirubin removal

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dc.contributor.authorCetin, Kemal
dc.date.accessioned2024-02-23T14:13:37Z
dc.date.available2024-02-23T14:13:37Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractIn this study, for the first time, micro-engineered cryogels embedded with Fe3O4 nanoparticles were developed as magnetic adsorbents. Magnetically controllable microcryogels were produced on a microstencil array chip by cryopolymerization and functionalized by polyethylenimine, as an affinity ligand. Macroporous architecture of both magnetic and non-magnetic microcryogels were evaluated via field emission scanning microscopy. Bilirubin adsorption studies were performed to investigate the optimal removal conditions. The results indicated that the adsorption capacity of magnetic microcryogels increased with higher temperature values while decreased with higher salt concentrations. Plasma bilirubin removal assay showed that the removal of MMs-PEI was much higher (i.e., 13-fold) than that of MMs. Magnetic microcryogels exhibited significant reusability, where the adsorption capacity decreased by 7.8 % after 5 adsorption-desorption cycles. The results showed that magnetic micro-engineered cryogels provided good application potential for bilirubin removal and an alternative for the current methods.en_US
dc.identifier.doi10.1016/j.procbio.2021.12.004
dc.identifier.endpage208en_US
dc.identifier.issn1359-5113
dc.identifier.issn1873-3298
dc.identifier.scopus2-s2.0-85120902787en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage203en_US
dc.identifier.urihttps://doi.org/10.1016/j.procbio.2021.12.004
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12503
dc.identifier.volume112en_US
dc.identifier.wosWOS:000731831400003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofProcess Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAffinity Bindingen_US
dc.subjectBilirubinen_US
dc.subjectCryogelsen_US
dc.subjectMagnetic Nanoparticlesen_US
dc.subjectMicrocryogelsen_US
dc.titleMagnetic nanoparticles embedded microcryogels for bilirubin removalen_US
dc.typeArticleen_US

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