Comparison of the ratio of second trimester fetal biometric measurements to fetal nasal bone length in fetuses with normal karyotype and trisomy 21

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dc.contributor.authorDal, Yusuf
dc.contributor.authorAkkus, Fatih
dc.contributor.authorKaragun, Sebnem
dc.contributor.authorCoskun, Ayhan
dc.date.accessioned2024-02-23T13:03:27Z
dc.date.available2024-02-23T13:03:27Z
dc.date.issued2024
dc.departmentNEÜen_US
dc.description.abstractAim: In this study, we compared the ratio of second trimester fetal biometric measurements to nasal bone length (NBL) in fetuses with normal karyotype and trisomy 21 to determine their diagnostic prognostic value. Materials and Methods: The study included 148 pregnant women who obtained second-trimester ultrasonographic fetal anatomy and had amniocentesis (AS) for fetal karyotyping. The fetal karyotype results divided the groups into normal and trisomy 21 fetuses. Age, obstetric history, first and/or second trimester screening test risk ratios, fetal biometric measurements, and NBL mm, median (MoM) multiples, and percentile values were recorded and compared between groups. Results: BPD/NBL ratios above 9.26 predict trisomy 21 in fetuses with 77.6% sensitivity and 86.1% specificity (p = 0.001). HC/NBL ratios above 34.50 predict trisomy 21 in fetuses with 77.8% sensitivity and 88.8% specificity (p = 0.001). FL/NBL ratios above 6.02 predict trisomy 21 in fetuses with 69.6% sensitivity and 72.2% specificity (p = 0.001). HL/NB ratios above 6.56 predict trisomy 21 in fetuses with 95.5% sensitivity and 47.2% specificity (p = 0.001). The NBL MoM value demonstrated a high diagnostic accuracy for normal-karyotype fetuses (p = 0.021). Conclusion: We found that BPD/NBL, HC/NBL, FL/NBL, and HL/NBL ratios differed between fetuses with a normal karyotype and those with trisomy 21, specifically the HC/NBL ratio, which predicted trisomy 21 with good diagnostic accuracy. In identifying normal-karyotype fetuses, the NBL MoM was highly accurate.en_US
dc.identifier.doi10.1002/jcu.23638
dc.identifier.issn0091-2751
dc.identifier.issn1097-0096
dc.identifier.pmid38318757en_US
dc.identifier.scopus2-s2.0-85184233504en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1002/jcu.23638
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10620
dc.identifier.wosWOS:001158158500001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Clinical Ultrasounden_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiparietal Diameteren_US
dc.subjectFemur Lengthen_US
dc.subjectHead Circumferenceen_US
dc.subjectHumerus Lengthen_US
dc.subjectNasal Boneen_US
dc.subjectTrisomy 21en_US
dc.titleComparison of the ratio of second trimester fetal biometric measurements to fetal nasal bone length in fetuses with normal karyotype and trisomy 21en_US
dc.typeArticleen_US

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