Neutrophil Lymphocyte Ratio as a Predictor of Stroke

Basit Öğe Kaydı
dc.contributor.authorTokgoz, Serhat
dc.contributor.authorKayrak, Mehmet
dc.contributor.authorAkpinar, Zehra
dc.contributor.authorSeyithanoglu, Abdullah
dc.contributor.authorGuney, Figen
dc.contributor.authorYuruten, Betigul
dc.date.accessioned2024-02-23T14:13:03Z
dc.date.available2024-02-23T14:13:03Z
dc.date.issued2013
dc.departmentNEÜen_US
dc.description.abstractBackground: The aim of this study is to investigate the relationship of the neutrophil to lymphocyte ratio (NLR) with short-term mortality in acute stroke. Methods: This retrospective study included 255 patients with acute cerebral infarction who presented within 24 hours of symptom onset. A hemogram from peripheral venous blood samples was taken at the time of admission. The NLR was calculated as the ratio of neutrophils to lymphocytes. Duration of follow-up was defined as 60 days. Results: Seventy-one of 255 patients died during the follow-up period. The median NLR was significantly increased among the mortality group compared with the survival group (median 11.50, interquartile ratio [IQR] 10.40 vs median 3.79, IQR 4.72; P = .001). In our multivariate Cox regression model, NLR >5.0 (hazard ratio [HR] 3.30; 95% confidence interval [CI] 1.35-8.07), National Institutes of Health Stroke Scale score (HR 1.11; 95% CI 1.07-1.16), glucose values at admission (HR 1.007; 95% CI 1.002-1.011), and history of coronary artery disease (HR 2.49; 95% CI 1.26-4.92) were predictors of short-term mortality. The sensitivity for short-term mortality when the NLR was >5 was 83.10%, and the specificity was 62.00%. The positive predictive value of a NLR >5 was 45.7%, and negative predictive value was 90.50%. A strong linear association between NLR and National Institutes of Health Stroke Scale score was also observed (r = 0.64; P = .001). In addition, the NLR was higher in both the atherosclerotic and cardioembolic stroke subgroups than the lacunar infarct subgroup (6.5 [IQR 7.2], 7.5 [IQR 8.9], and 3.20 [IQR 3.50], respectively; P = .001). Conclusions: The NLR at the time of hospital admission may be a predictor of short-term mortality in acute stroke patients. Because of the routine use and inexpensive nature of hemogram analysis, the NLR should be investigated in future prospective, randomized controlled trials investigating acute stroke.en_US
dc.identifier.doi10.1016/j.jstrokecerebrovasdis.2013.01.011
dc.identifier.endpage1174en_US
dc.identifier.issn1052-3057
dc.identifier.issn1532-8511
dc.identifier.issue7en_US
dc.identifier.pmid23498372en_US
dc.identifier.scopus2-s2.0-84880135194en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1169en_US
dc.identifier.urihttps://doi.org/10.1016/j.jstrokecerebrovasdis.2013.01.011
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12282
dc.identifier.volume22en_US
dc.identifier.wosWOS:000325874200084en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofJournal Of Stroke & Cerebrovascular Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMortalityen_US
dc.subjectNational Institutes Of Health Stroke Scaleen_US
dc.subjectNeutrophil Lymphocyte Ratioen_US
dc.subjectStrokeen_US
dc.titleNeutrophil Lymphocyte Ratio as a Predictor of Strokeen_US
dc.typeArticleen_US

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