Efficacy of pulsed-light accelerated crosslinking in the treatment of progressive keratoconus: Two-year results
Küçük Resim Yok
Tarih
2020
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Sage Publications Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose: The aim of this study was to evaluate the 2-year results of epithelium-off pulsed-light accelerated corneal collagen crosslinking treatment in progressive keratoconus using 30 mW/cm(2) ultraviolet A light for 6 min with a total dose of 5.4 J/cm(2). Methods: A total of 30 eyes of 22 patients with documented progressive keratoconus and treated with epithelium-off pulsed-light accelerated corneal collagen crosslinking using the KXL (R) crosslinking device (Avedro Inc, Waltham, MA, USA) were included in this retrospective study. Corneal tomographic measurements and best spectacle-corrected visual acuity were compared using analysis of variance with repeated measurements between the baseline visit (before the corneal collagen crosslinking treatment), and the sixth month, first, and second year visits. Results: Flat keratometry (K1), steep keratometry (K2), and mean keratometry (Km) decreased significantly at sixth month, first, and second years (p < 0.001, p = 0.001, and p < 0.001, respectively). Maximum keratometry (Kmax) decreased from 55.40 +/- 4.90 D at baseline to 54.82 +/- 4.68 D, 54.80 +/- 5.12 D, and 54.65 +/- 5.36 D at sixth month, first year, and second year, respectively (p = 0.007). The best spectacle-corrected visual acuity improved from 0.34 +/- 0.24 logMAR at baseline to 0.25 +/- 0.16 logMAR, 0.22 +/- 0.15 logMAR, and 0.17 +/- 0.13 logMAR at sixth month, first year, and second year, respectively (p < 0.001). At the second year visit, best spectacle-corrected visual acuity remained stable (no lines lost) with respect to the baseline in 8 eyes and increased 1 or more lines in 22 eyes. Conclusion: Pulsed-light accelerated corneal collagen crosslinking using 30 mW/cm(2) ultraviolet A light for 6 min with a total dose of 5.4 J/cm(2) is an effective treatment modality in cases with progressive keratoconus-it stops progression at 2 years also regresses some of the cases.
Açıklama
Anahtar Kelimeler
Keratoconus, Accelerated Crosslinking, Pulsed Ultraviolet A Light
Kaynak
European Journal Of Ophthalmology
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
30
Sayı
6
