Ischemia-Modified Albumin and Atherosclerosis in Patients With Familial Mediterranean Fever

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dc.contributor.authorKucuk, Adem
dc.contributor.authorUslu, Ali Ugur
dc.contributor.authorArslan, Sevket
dc.contributor.authorBalta, Sevket
dc.contributor.authorOzturk, Cengiz
dc.contributor.authorUysal, Saliha
dc.contributor.authorYilmaz, Ramazan
dc.date.accessioned2024-02-23T14:26:48Z
dc.date.available2024-02-23T14:26:48Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractThe constriction of vessels due to atherosclerotic lesions causes hypoxia/ischemia and oxidative changes resulting in transformation of free albumin to ischemia-modified albumin (IMA) in the circulation and increased carotid intima-media thickness (cIMT). We investigated the reliability of IMA increase in evaluating atherosclerosis in patients with familial Mediterranean fever (FMF) compared with cIMT. Patients with FMF (n = 58) diagnosed by the Tel-Hashomer criteria in attack-free period and 38 healthy people were included in the study. Patient demographics as well as the clinical and laboratory characteristics of the healthy controls and patients with FMF were noted. The IMA levels and cIMT in patients with FMF were 0.30 +/- 0.09 absorbance units (ABSUs) and 1.12 +/- 0.27 mm, respectively, and in the control group, IMA levels and cIMT were 0.25 +/- 0.07 ABSU and 0.74 +/- 0.26 mm, respectively. The IMA levels and cIMT were significantly higher in patients with FMF than in controls (P = .020 and P < .0001, respectively). The IMA values showed positive correlation with cIMT in patients with FMF(r = .302, P = .041). Our results reveal that IMAan oxidative stress markermay be an indicator of atherosclerosis in patients with FMF. This finding deserves further investigation.en_US
dc.identifier.doi10.1177/0003319715595744
dc.identifier.endpage460en_US
dc.identifier.issn0003-3197
dc.identifier.issn1940-1574
dc.identifier.issue5en_US
dc.identifier.pmid26238112en_US
dc.identifier.scopus2-s2.0-84963778798en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage456en_US
dc.identifier.urihttps://doi.org/10.1177/0003319715595744
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14339
dc.identifier.volume67en_US
dc.identifier.wosWOS:000374298500010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofAngiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFamilial Mediterranean Feveren_US
dc.subjectAtherosclerosisen_US
dc.subjectCarotid Intima-Media Thicknessen_US
dc.subjectIschemia-Modified Albuminen_US
dc.subjectSystemic Inflammationen_US
dc.titleIschemia-Modified Albumin and Atherosclerosis in Patients With Familial Mediterranean Feveren_US
dc.typeArticleen_US

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