Serum levels of cortisol, dehydroepiandrosterone, and oxytocin in children with attention-deficit/hyperactivity disorder combined presentation with and without comorbid conduct disorder

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dc.contributor.authorIsik, Umit
dc.contributor.authorBilgic, Ayhan
dc.contributor.authorToker, Aysun
dc.contributor.authorKilinc, Ibrahim
dc.date.accessioned2024-02-23T14:13:39Z
dc.date.available2024-02-23T14:13:39Z
dc.date.issued2018
dc.departmentNEÜen_US
dc.description.abstractThe present study aimed to investigate serum cortisol, dehydroepiandrosterone (DHEA), and oxytocin levels of children with attention-deficit/hyperactivity disorder (ADHD) combined presentation and those diagnosed with ADHD combined presentation and coexisting conduct disorder. A total of 74 drug-naive children with ADHD combined presentation alone, 32 children with ADHD combined presentation + conduct disorder, and 42 healthy controls were included. The severities of ADHD and conduct disorder symptoms were assessed via parent- and teacher-rated questionnaires. The severity of aggression, anxiety, and depression symptoms of the children were assessed by the self-report inventories. Independent of potential confounders, including age, sex, pubertal stage, and severity of depression and anxiety, serum oxytocin levels of the ADHD combined presentation + conduct disorder group were significantly lower than those of both the ADHD combined presentation alone and control groups. There was also a trend for the ADHD combined presentation + conduct disorder group to show lower serum DHEA levels than that of the ADHD combined presentation alone group. However, serum cortisol levels did not show significant alterations among the groups. These findings suggest that oxytocin and DHEA may play a role in the pathophysiology of conduct disorder, at least in the presence of ADHD combined presentation.en_US
dc.identifier.doi10.1016/j.psychres.2017.12.076
dc.identifier.endpage219en_US
dc.identifier.issn0165-1781
dc.identifier.pmid29324397en_US
dc.identifier.scopus2-s2.0-85040108603en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage212en_US
dc.identifier.urihttps://doi.org/10.1016/j.psychres.2017.12.076
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12516
dc.identifier.volume261en_US
dc.identifier.wosWOS:000426222600034en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofPsychiatry Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAttention-Deficit/Hyperactivity Disorderen_US
dc.subjectConduct Disorderen_US
dc.subjectCortisolen_US
dc.subjectDehydroepiandrosteroneen_US
dc.subjectOxytocinen_US
dc.titleSerum levels of cortisol, dehydroepiandrosterone, and oxytocin in children with attention-deficit/hyperactivity disorder combined presentation with and without comorbid conduct disorderen_US
dc.typeArticleen_US

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