Carbon quantum dot modified electrodes developed for electrochemical monitoring of Daunorubicin-DNA interaction

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dc.contributor.authorEksin, Ece
dc.contributor.authorSenturk, Huseyin
dc.contributor.authorZor, Erhan
dc.contributor.authorBingol, Haluk
dc.contributor.authorErdem, Arzum
dc.date.accessioned2024-02-23T14:12:46Z
dc.date.available2024-02-23T14:12:46Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractThe carbon quantum dot (cQD) modified disposable pencil graphite electrodes were developed for the first time in this study for electrochemical monitoring of drug-DNA interaction. The biomolecular interaction between calf thymus double stranded DNA (ctDNA) and an anthracycline antineoplastic drug, Daunorubicin (DNR) was investigated by differential pulse voltammetry (DPV) technique. For this purpose, experimental conditions, such as, the concentration of ctDNA, concentration of DNR and interaction time were optimized. Under optimum conditions, the detection limits of DNR and ctDNA were found to be 0.02 mu g/mL and 0.89 mu g/mL, respectively. The effect of interaction time between DNR and ctDNA was explored upon to the changes at both DNR and guanine oxidation signals. Drug-DNA interaction process was also examined by electrochemical impedance spectroscopy (EIS) technique.en_US
dc.description.sponsorshipTurkish Academy of Sciences (TUBA)en_US
dc.description.sponsorshipA.E. would like to express her gratitude to the Turkish Academy of Sciences (TUBA) as a Principal member for its partial support.en_US
dc.identifier.doi10.1016/j.jelechem.2020.114011
dc.identifier.issn1572-6657
dc.identifier.issn1873-2569
dc.identifier.scopus2-s2.0-85080978920en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.jelechem.2020.114011
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12176
dc.identifier.volume862en_US
dc.identifier.wosWOS:000525903900028en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofJournal Of Electroanalytical Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCarbon Quantum Doten_US
dc.subjectPencil Graphite Electrodesen_US
dc.subjectDrug-Dna Interactionen_US
dc.subjectDifferential Pulse Voltammetryen_US
dc.subjectElectrochemical Impedance Spectroscopyen_US
dc.titleCarbon quantum dot modified electrodes developed for electrochemical monitoring of Daunorubicin-DNA interactionen_US
dc.typeArticleen_US

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