Systemic Inflammation Response Index and Systemic Immune Inflammation Index Are Associated with Clinical Outcomes in Patients with Acute Pancreatitis?

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dc.contributor.authorBiyik, Murat
dc.contributor.authorBiyik, Zeynep
dc.contributor.authorAsil, Mehmet
dc.contributor.authorKeskin, Muharrem
dc.date.accessioned2024-02-23T14:20:17Z
dc.date.available2024-02-23T14:20:17Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractObjectives: The inflammatory response is critically important in acute pancreatitis (AP). Systemic immune-inflammation (SII) index and systemic inflammation response index (SIRI), which are novel inflammatory markers, have been linked to determining outcomes in various diseases. The goal of the current study was to examine the relation of the SII index and SIRI with disease severity and acute kidney injury (AKI) in subjects with AP. Methods: A total of 332 subjects with AP were analyzed retrospectively. SII index was calculated using the formula; platelet (P)xneutrophil (N)/lymphocyte (L), while SIRI was calculated as N x monocyte (M)/L count. Multivariate regression (MR) was done to determine the independent risk factors for AKI and severe AP (SAP). Results: Statistical analyses showed that both median SII index and median SIRI increased gradually with higher AP severity (p < 0.001). Both SII index and SIRI were higher in subjects with AKI compared to controls (p < 0.001). Using MR analysis, the SII index was found to independently predict both SAP (OR = 1.004, 95% CI: 1.001-1.008, p = 0.018) and AKI (OR = 1.005, 95% CI: 1.003-1.008, p < 0.001). ROC analysis showed that the SII index could accurately differentiate SAP (AUC = 0.809, p < 0.001) and AKI (AUC = 0.820, p = 0.001) in patients with acute pancreatitis. ROC analysis also showed that SIRI could also accurately differentiate SAP (0.782, p < 0.001) and AKI (AUC = 0.776, p = 0.001). Conclusions: SIRI and the SII indexes can be used as potential biomarkers in predicting both disease severity and AKI development in subjects with AP.en_US
dc.identifier.doi10.1080/08941939.2022.2084187
dc.identifier.endpage1620en_US
dc.identifier.issn0894-1939
dc.identifier.issn1521-0553
dc.identifier.issue8en_US
dc.identifier.pmid35855674en_US
dc.identifier.scopus2-s2.0-85131591755en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1613en_US
dc.identifier.urihttps://doi.org/10.1080/08941939.2022.2084187
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13102
dc.identifier.volume35en_US
dc.identifier.wosWOS:000806112100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal Of Investigative Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute Pancreatitisen_US
dc.subjectAcute Kidney Injuryen_US
dc.subjectSystemic Inflammation Response Indexen_US
dc.subjectSystemic Immune Inflammation Indexen_US
dc.subjectSii Indexen_US
dc.subjectSirien_US
dc.titleSystemic Inflammation Response Index and Systemic Immune Inflammation Index Are Associated with Clinical Outcomes in Patients with Acute Pancreatitis?en_US
dc.typeArticleen_US

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