Studies on the reproductive effects of chronic treatment with agomelatine in the rat

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dc.contributor.authorCanpolat, Sinan
dc.contributor.authorUlker, Nazife
dc.contributor.authorYardimci, Ahmet
dc.contributor.authorBulmus, Ozgur
dc.contributor.authorOzdemir, Gokcen
dc.contributor.authorSahin, Zafer
dc.contributor.authorErcan, Zubeyde
dc.date.accessioned2024-02-23T14:02:45Z
dc.date.available2024-02-23T14:02:45Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractAgomelatine is an antidepressant with a novel mechanism of action. It is a melatonergic agonist for MT1 and MT2 receptors and a serotonin (5-HT2C) receptor antagonist. Agomelatine has been suggested not to have adverse effects on sexual functions. However, the effects of chronic agomelatine administration on reproductive functions have not been sufficiently studied in animal models. We mainly aimed to explore the effects of agomelatine on reproductive functions in the male and female rats. For the experimental studies, Sprague Dawley rats were used. The animals started to receive daily oral agomelatine (10 mg/kg) on post-natal day 21. Agomelatine advanced vaginal opening in the female rats whereas it delayed puberty onset in the male rats. Agomelatine treatment significantly decreased intromission frequencies, which indicates a facilitator role of this antidepressant on male sexual behavior. In the forced swimming test (FST) used for assessing antidepressant efficacy, agomelatine induced a significant decrease in duration of immobility, and an increase in the swimming time, respectively, which confirms the antidepressant-like activity of agomelatine. The present findings suggest that agomelatine shows a strong antidepressant effect in the male rats without any adverse influences on sexual behavior, and its effects on pubertal maturation seem to show sex-dependent differences. (C) 2015 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipTUBITAK [113S193]en_US
dc.description.sponsorshipThis work was supported by TUBITAK - 113S193.en_US
dc.identifier.doi10.1016/j.ejphar.2015.11.054
dc.identifier.endpage39en_US
dc.identifier.issn0014-2999
dc.identifier.issn1879-0712
dc.identifier.pmid26643170en_US
dc.identifier.scopus2-s2.0-84948808955en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage33en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejphar.2015.11.054
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11835
dc.identifier.volume770en_US
dc.identifier.wosWOS:000367230700005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofEuropean Journal Of Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAgomelatineen_US
dc.subjectAntidepressanten_US
dc.subjectSexual Behavioren_US
dc.titleStudies on the reproductive effects of chronic treatment with agomelatine in the raten_US
dc.typeArticleen_US

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