Evaluation of Mutagenic Activities of Antimicrobial Benzoxazole Derivatives

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dc.contributor.authorAydogan, Zeliha
dc.contributor.authorFoto, Fatma Zilifdar
dc.contributor.authorFoto, Egemen
dc.contributor.authorTemiz-Arpaci, Ozlem
dc.contributor.authorDiril, Nuran
dc.date.accessioned2024-02-23T13:59:25Z
dc.date.available2024-02-23T13:59:25Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractBenzoxazoles are heterocyclic compounds containing fused benzene and oxazole rings, which have been reported to possess antibacterial, antitubercular, antifungal, antiviral, antioxidant and anticancer activities. In this study, the mutagenic properties of fifteen benzoxazole derivatives reported previously to exhibit broad antimicrobial and potent antitumor effects were investigated for their genotoxic potential by employing the Ames test. The Ames test was conducted using Salmonella typhimurium TA98, TA100 and TA102 tester strains in the standard plate incorporation assay with and without liver S9 fraction. The results were evaluated statistically and no mutagenic activity of test drugs was observed. Relationship between the structure and cytotoxic activity of compounds was evaluated using the SAR method based on data obtained via the Ames test system.en_US
dc.description.sponsorshipHacettepe University Research Fund; [012 D06 60107]en_US
dc.description.sponsorshipThis work was supported by the Hacettepe University Research Fund (Grant no. 012 D06 60107).en_US
dc.identifier.doi10.1007/s11094-022-02776-y
dc.identifier.endpage1198en_US
dc.identifier.issn0091-150X
dc.identifier.issn1573-9031
dc.identifier.issue9en_US
dc.identifier.scopus2-s2.0-85143417774en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage1192en_US
dc.identifier.urihttps://doi.org/10.1007/s11094-022-02776-y
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11178
dc.identifier.volume56en_US
dc.identifier.wosWOS:000894657300004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPharmaceutical Chemistry Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmes Testen_US
dc.subjectSalmonella Typhimuriumen_US
dc.subjectMutagenicityen_US
dc.subjectBenzoxazolesen_US
dc.titleEvaluation of Mutagenic Activities of Antimicrobial Benzoxazole Derivativesen_US
dc.typeArticleen_US

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