Assessment of Corneal Sensation, Innervation and Retinal Nerve Fiber Layer in Patients Treated with Multiple Intravitreal Ranibizumab Injections

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dc.contributor.authorBitirgen, Gulfidan
dc.contributor.authorBelviranli, Selman
dc.contributor.authorMalik, Rayaz A.
dc.contributor.authorKerimoglu, Hurkan
dc.contributor.authorSatirtav, Gunhal
dc.contributor.authorZengin, Nazmi
dc.date.accessioned2024-02-23T14:29:26Z
dc.date.available2024-02-23T14:29:26Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractPurpose To evaluate the effects of repeated intravitreal ranibizumab injections on corneal sensitivity, corneal sub-basal nerve plexus (SBNP) and peripapillary retinal nerve fiber layer (RNFL) thickness in patients with neovascular age-related macular degeneration (AMD). Methods Sixty-six eyes of 33 patients who had received unilateral repeated intravitreal ranibizumab injections (0.5 mg/0.05 ml) for the treatment of AMD and 25 eyes of 25 healthy subjects were included in the study. Central corneal sensation was measured using the contact Cochet-Bonnet esthesiometer. The laser scanning in vivo corneal confocal microscope was used to determine corneal SBNP parameters. The peripapillary RNFL thickness was assessed with spectral-domain optical coherence tomography. Data obtained from the ranibizumab-injected eyes were compared with those of the fellow non-treated eyes and the eyes of the healthy control subjects. Results The mean number of ranibizumab injections per eye was 8.9 +/- 5.0 (range 3-20). There were no statistically significant differences in the central corneal sensitivity threshold and corneal SBNP parameters between the ranibizumab-injected eyes and the fellow untreated eyes or between those with neovascular AMD and the healthy control group (P>0.05 for all). The average peripapillary RNFL thickness of the treated eyes did not differ significantly to the fellow eyes (P=0.237), and the eyes of healthy control subjects (P=0.918). There were no significant correlations between the number of ranibizumab injections and any of the study parameters. Conclusions Multiple intravitreal injections of ranibizumab seem to have no harmful effects on corneal sensitivity, innervation and peripapillary RNFL thickness in patients with AMD.en_US
dc.description.sponsorshipScientific Research Fund of the Necmettin Erbakan University [151218003]en_US
dc.description.sponsorshipThis work was supported by the Scientific Research Fund of the Necmettin Erbakan University (Project Number: 151218003) (GB). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en_US
dc.identifier.doi10.1371/journal.pone.0170271
dc.identifier.issn1932-6203
dc.identifier.issue1en_US
dc.identifier.pmid28085965en_US
dc.identifier.scopus2-s2.0-85009275209en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0170271
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14698
dc.identifier.volume12en_US
dc.identifier.wosWOS:000391972600082en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPublic Library Scienceen_US
dc.relation.ispartofPlos Oneen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[Keyword Not Available]en_US
dc.titleAssessment of Corneal Sensation, Innervation and Retinal Nerve Fiber Layer in Patients Treated with Multiple Intravitreal Ranibizumab Injectionsen_US
dc.typeArticleen_US

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