8-F2-isoprostane, thioredoxin and thioredoxin reductase levels in children with obsessive-compulsive disorder

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dc.contributor.authorBilgic, Ayhan
dc.contributor.authorSivri, Rukiye Colak
dc.contributor.authorKilinc, Ibrahim
dc.date.accessioned2024-02-23T14:20:15Z
dc.date.available2024-02-23T14:20:15Z
dc.date.issued2018
dc.departmentNEÜen_US
dc.description.abstractPurpose: Accumulating data demonstrate that oxidative stress may play a crucial role in obsessive-compulsive disorder (OCD). This study aimed to investigate the role of 8-F2-isoprostane, thioredoxin (Trx), and thioredoxin reductase (TrxR) in children with OCD.Materials and methods: Thirty-three drug-free children with OCD and 35 healthy controls were included in this study. The severity of OCD symptoms was assessed via the Children's Yale Brown Obsessive-Compulsive Scale. The severity of anxiety levels was determined through the Screen for Child Anxiety-Related Emotional Disorders. Plasma levels of 8-F2-isoprostane, Trx, and TrxR were measured using commercial enzyme-linked immunosorbent assay kits.Results: Plasma 8-F2-isoprostane, Trx, and TrxR levels did not show any significant differences between patient and control groups. There were no significant correlations between plasma levels of these antioxidants and severity of OCD.Conclusions: Findings of this study did not support the involvement of oxidative stress in the etiology of childhood OCD.en_US
dc.description.sponsorshipScientific Research Project Coordination Unit of Necmettin Erbakan University [171218002]en_US
dc.description.sponsorshipFunding for this study was provided by a grant from the Scientific Research Project Coordination Unit of Necmettin Erbakan University (Project no: 171218002).en_US
dc.identifier.doi10.1080/08039488.2018.1484512
dc.identifier.endpage488en_US
dc.identifier.issn0803-9488
dc.identifier.issn1502-4725
dc.identifier.issue7en_US
dc.identifier.pmid29927677en_US
dc.identifier.scopus2-s2.0-85048753803en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage484en_US
dc.identifier.urihttps://doi.org/10.1080/08039488.2018.1484512
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13089
dc.identifier.volume72en_US
dc.identifier.wosWOS:000456435500005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofNordic Journal Of Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectObsessive-Compulsive Disorderen_US
dc.subject8-F2-Isoprostaneen_US
dc.subjectThioredoxinen_US
dc.subjectThioredoxin Reductaseen_US
dc.subjectChildrenen_US
dc.title8-F2-isoprostane, thioredoxin and thioredoxin reductase levels in children with obsessive-compulsive disorderen_US
dc.typeArticleen_US

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