Normative data assessment of age-related changes in macular and optic nerve head vessel density using optical coherence tomography angiography

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dc.contributor.authorAbay, Rafiye Nur
dc.contributor.authorAkdeniz, Gunhal Satirtav
dc.contributor.authorKatipoglu, Zeynep
dc.contributor.authorKerimoglu, Hurkan
dc.date.accessioned2024-02-23T14:13:22Z
dc.date.available2024-02-23T14:13:22Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractObjective: To investigate macular and optic nerve head vessel density in healthy individuals using optical coherence tomography angiography (OCTA), and determine their relationship with age. Method: This retrospective study included 153 eyes of 153 individuals aged between 20 and 80 years, who had no systemic diseases, optic disk, or retinal pathologies. The retinal (6 x 6 mm) and optic disk (4.5 x 4.5 mm) OCTA images were evaluated for superficial capillary plexus (SCP), deep capillary plexus (DCP) and radial peripapillary capillary plexus (RPCP) vessel density, foveal avascular zone (FAZ) area, and choriocapillaris flow area and compared among 5 age groups. Results: The SCP vessel density was significantly associated with age for the whole image (P = 0.001), parafovea (P = 0.038), and perifovea (P/ce:italic >= 0.001). The DCP vessel density significantly varied with age in the whole image (P = 0.004), parafovea (P = 0.001), and perifovea (P = 0.002). The SCP and DCP vessel densities were significantly lower in the older age groups, and more prominently so after 50 years of age. The FAZ area increased with age; however, this finding was not statistically significant (P = 0.660). The choriocapillaris flow area decreased with age (P = 0.002). The RPCP vessel density in the inside disk significantly decreased with age (P = 0.038). Conclusion: Age should be taken into consideration when using OCTA in the diagnosis and follow-up of retinal and optic nerve diseases. It is believed that the results here in can be used as a reference baseline for future studies.en_US
dc.identifier.doi10.1016/j.pdpdt.2021.102624
dc.identifier.issn1572-1000
dc.identifier.issn1873-1597
dc.identifier.pmid34775064en_US
dc.identifier.scopus2-s2.0-85119674407en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.pdpdt.2021.102624
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12414
dc.identifier.volume37en_US
dc.identifier.wosWOS:000782281300002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofPhotodiagnosis And Photodynamic Therapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRetinaen_US
dc.subjectOptic Disken_US
dc.subjectMaculaen_US
dc.subjectOptical Coherence Tomography Angiographyen_US
dc.subjectVessel Densityen_US
dc.titleNormative data assessment of age-related changes in macular and optic nerve head vessel density using optical coherence tomography angiographyen_US
dc.typeArticleen_US

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