Prognostic Significance of Radiologic Extranodal Extension in Nasopharyngeal Cancer

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dc.contributor.authorEryilmaz, Melek Karakurt
dc.contributor.authorKadiyoran, Cengiz
dc.date.accessioned2024-02-23T14:26:56Z
dc.date.available2024-02-23T14:26:56Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractObjective. The aim of the present study was to evaluate the prognostic value of radiologic extranodal extension (rENE) in patients with nasopharyngeal cancer. Study Design. Retrospective review. Setting. Tertiary university hospital. Methods. We identified patients with nasopharyngeal cancer and lymph node metastasis who underwent pretreatment neck computed tomography or magnetic resonance imaging and evaluated rENE from the involved lymph node. Univariate Kaplan-Meier and multivariate Cox regression analyses were used to compare rENE1 and rENE- groups for local regional relapse-free survival, distant metastasis-free survival, and overall survival. Results. Of 61 cases, 24 (39.3%) were rENE1 and 37 (60.7%) were rENE-. The median follow-up was 65.5 months. The 5-year distant metastasis-free survival and overall survival rates were lower in the rENE1 group than the rENE- group (70.8% vs 89.2%, P =.016; 66.7% vs 89.2%, P =.01, respectively). Differences in locoregional control between the groups were not significant (P =.18). The 5-year rates for local regional relapse-free survival were 87.5% for rENE1 and 91.9% for rENE-. In multivariate analysis, the presence of rENE was a significant independent adverse prognostic factor for distant metastasis-free survival and overall survival. Conclusions. We showed that rENE is an independent prognostic factor for poor distant control and survival in patients with nasopharyngeal cancer.en_US
dc.identifier.doi10.1177/01945998211008887
dc.identifier.endpage326en_US
dc.identifier.issn0194-5998
dc.identifier.issn1097-6817
dc.identifier.issue2en_US
dc.identifier.pmid33874793en_US
dc.identifier.scopus2-s2.0-85104815130en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage321en_US
dc.identifier.urihttps://doi.org/10.1177/01945998211008887
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14379
dc.identifier.volume166en_US
dc.identifier.wosWOS:000682569200001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofOtolaryngology-Head And Neck Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectExtranodal Extensionen_US
dc.subjectNasopharyngeal Canceren_US
dc.subjectComputed Tomography And Magnetic Resonance Imagingen_US
dc.titlePrognostic Significance of Radiologic Extranodal Extension in Nasopharyngeal Canceren_US
dc.typeArticleen_US

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