THE LEVELS OF ADENOSINE TRIPHOSPHATE SYNTHASE 6, MANGANESE SUPEROXIDE DISMUTASE, NADPH-CYTOCHROME P450 REDUCTASE, LACTATE DEHYDROGENASE IN SEMINAL PLASMA OF OLIGOZOOSPERMIA AND NORMOZOOSPERMIA MEN
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Nobel Ilac
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: In recent years, energy production and enzymes in mitochondrial pathways are an important in male fertilization.Material and Method: For this purpose, we tried to determine the relationship between normozoospermia and oligozoospermia individuals according to levels of some mitochondrial enzymes. The seminal plasma levels of mitochondrial encoded adenosine triphosphate synthase 6 (mtATP6), manganese superoxide dismutase (Mn-SOD), NADPH-cytochrome P450 reductase (CPR), lactate dehydrogenase (LDH) were analyzed and assessed their correlations between data of spermogram. The study was composed of two groups consisting of normozoospermic and oligozoospermic volunteers.Results: mtATP6 levels were significantly higher in normozoospermia (0.97 & PLUSMN;0.50 ng/mg protein, p=0.008) than oligozoospermia (0.64 & PLUSMN;0.32 ng/mg protein). LDH levels were higher in normozoospermia (0.25 & PLUSMN;0.074 U/ mg protein, p=0.007) than oligozoospermia (0.199 & PLUSMN;0.049 ng/mg protein). The groups did not differ in terms of MnSOD and CPR levels. mtATP6 levels were significantly correlated with sperm concentration, total number and total motility, immotility, total progressive motile sperm count (TPMSC) and long head anomaly. LDH levels were related with long head and short tail anomaly.Conclusion: We observed some of the spermatogenetic anomalies are caused by defects in energy regulation. We did not find any evidence on MnSOD and CPR activity regarded as determinative parameters in response to increased oxidative stress in oligozoospermia.
Açıklama
Anahtar Kelimeler
Infertility, Mnsod, Ldh, Mtatp6, Cpr
Kaynak
Nobel Medicus
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
19
Sayı
2
