Can MitoTEMPO protect rat sciatic nerve against ischemia-reperfusion injury?

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dc.contributor.authorTuncer, Seckin
dc.contributor.authorAkkoca, Ahmet
dc.contributor.authorCelen, Murat Cenk
dc.contributor.authorDalkilic, Nizamettin
dc.date.accessioned2024-02-23T13:43:32Z
dc.date.available2024-02-23T13:43:32Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractAbdominal ischemia-reperfusion (I/R) is known to cause both structural and functional damage to sciatic nerve which is related to the oxidative stress. We investigated the protective effects of mitochondria-targeted antioxidant (2-(2,2,6,6-tetramethylpiperidin-1-oxyl-4-ylamino)-2-oxoethyl) triphenylphosphonium chloride (MitoTEMPO) on ischemia-reperfusion-induced nerve damage by using the conduction velocity distribution (CVD) calculations from in vitro compound nerve action potential (CNAP) recordings from rat sciatic nerve. Adult male Wistar albino rats were divided into three groups. The IR and IR + MT groups had aortic cross-clamping for 1 h followed by 2 h reperfusion, while SHAM group had the same procedure without cross-clamping. IR + MT group received 0.7 mg/kg/day MitoTEMPO injection for 28 days before I/R, while other groups received vehicle alone. Ischemia-reperfusion resulted in a significant decrease (p < .05) in maximum depolarizations (mV), areas (mV.ms), and maximum and minimum upstroke velocities (mV/ms) of CNAPs, while injection of MitoTEMPO showed a complete protective effect on these impairments. The histograms for CVD showed that I/R blocked the contribution of fast-conducting fibers (> 60 m/s). MitoTEMPO prevented that blockage and caused a shift in the CVD. Functional nerve damage caused by I/R can be prevented by MitoTEMPO, which can enter mitochondria, the main source of reactive oxygen species (ROS).en_US
dc.identifier.doi10.1007/s00210-020-02039-1
dc.identifier.endpage553en_US
dc.identifier.issn0028-1298
dc.identifier.issn1432-1912
dc.identifier.issue3en_US
dc.identifier.pmid33415504en_US
dc.identifier.scopus2-s2.0-85099098356en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage545en_US
dc.identifier.urihttps://doi.org/10.1007/s00210-020-02039-1
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10846
dc.identifier.volume394en_US
dc.identifier.wosWOS:000605924400002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofNaunyn-Schmiedebergs Archives Of Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMitotempoen_US
dc.subjectSciatic Nerveen_US
dc.subjectIschemia-Reperfusionen_US
dc.subjectConduction Velocity Distributionen_US
dc.titleCan MitoTEMPO protect rat sciatic nerve against ischemia-reperfusion injury?en_US
dc.typeArticleen_US

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