Evaluation of the effectiveness of the tuba uterina tubular flap in the peripheral nervous system regeneration in rats

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dc.contributor.authorYildirim, Mehmet Emin Cem
dc.contributor.authorDadaci, Mehmet
dc.contributor.authorInce, Bilsev
dc.contributor.authorUyar, Ilker
dc.contributor.authorYarar, Serhat
dc.contributor.authorOltulu, Pembe
dc.contributor.authorAygul, Recep
dc.date.accessioned2024-02-23T14:20:44Z
dc.date.available2024-02-23T14:20:44Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractNerve conduits could be used to provide a bridge between both nerve endings. In this study, the tuba uterina of female rats were prepared in a vascularized pedicled flap model and it used as a nerve conduit. The aim was to investigate the effectiveness of a vascularized pedicle nerve conduit and its ciliated epithelium in a sciatic nerve defect. The study was conducted between May and August 2018, and used a total of 60, 14-16-week-old female Wistar albino rats. Six groups were created; Cut and Unrepaired Group, Nerve Graft Group, Flap-Forward Group (Tuba uterina tubular flap, forward direction), Flap-Reversed Group (Tuba uterina tubular flap, reverse direction), Graft-Forward Group (Tuba uterina tubular graft, forward direction) and Graft-Reverse Group (Tuba uterina tubuler graft, reverse direction). Nerve regeneration was evaluated 3 months (90 days) after the surgery by the following methods: (1) Sciatic Functional Index (SFI) measurement, (2) Electromyographic (EMG) assessment, (3) Microscopic assessment with the light microscope and (4) Microscopic assessment with the electron microscope. According to the SFI, EMG and microscopic assessments with the light and electron microscope, it was observed that the transfer of tuba uterina tubular conduit as a graft was statistically better in its effect on nerve regeneration than flap transfer, but also indicated that the direction of the ciliated structures had no significant effect. We believe that as this model is improved with future studies, it will shed light on new models, ideas and innovations about nerve conduits.en_US
dc.identifier.doi10.1080/2000656X.2021.1934844
dc.identifier.endpage110en_US
dc.identifier.issn2000-656X
dc.identifier.issn2000-6764
dc.identifier.issue2en_US
dc.identifier.pmid34151711en_US
dc.identifier.scopus2-s2.0-85108263729en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage103en_US
dc.identifier.urihttps://doi.org/10.1080/2000656X.2021.1934844
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13276
dc.identifier.volume56en_US
dc.identifier.wosWOS:000664196300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal Of Plastic Surgery And Hand Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNerve Regenerationen_US
dc.subjectNerve Conduitsen_US
dc.subjectTuba Uterina Conduiten_US
dc.subjectPlastic Surgery Repairen_US
dc.subjectTissue Defecten_US
dc.subjectMicrovascularen_US
dc.titleEvaluation of the effectiveness of the tuba uterina tubular flap in the peripheral nervous system regeneration in ratsen_US
dc.typeArticleen_US

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