Exploratory study to evaluate plasma vasopressin and apelin-13 levels in children with attention-deficit hyperactivity disorder

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dc.contributor.authorBilgic, Ayhan
dc.contributor.authorToker, Aysun
dc.contributor.authorUysal, Saliha
dc.date.accessioned2024-02-23T14:24:34Z
dc.date.available2024-02-23T14:24:34Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractAimVasopressin exerts robust influences on social communication and behavior in humans. Apelin is a relatively novel neuropeptide that could counteract vasopressin's actions and has been shown to be closely related with a broad range of physiological functions. Abnormalities in vasopressin and apelin have been detected in a variety of psychiatric disorders, but their relation to attention-deficit hyperactivity disorder (ADHD) is unknown. In the present study, we explored the plasma levels of vasopressin and apelin-13 in children with ADHD. MethodsThirty-four children with ADHD and 36 healthy controls were enrolled in this study. The severity of ADHD symptoms was assessed via Conners' Parent Rating Scale and Conners' Teacher Rating Scale. Plasma levels of vasopressin and apelin-13 were measured using commercial enzyme-linked immunosorbent assay kits. ResultsThe mean plasma apelin-13 levels were significantly higher in male children with ADHD than in male control subjects; no significant difference was found between the groups for plasma apelin-13 levels in girls or in the entire subject cohort. Plasma vasopressin levels did not show any significant differences between groups. There were no significant correlations between plasma levels of these neuropeptides and scores for Conners' Parent Rating Scale and Conners' Teacher Rating Scale. ConclusionOur results suggest a sex-specific association between plasma apelin-13 levels and ADHD. Apelin-13 may play a role in the etiopathogenesis of ADHD either with a direct impact on the apelin receptor or via its opposing effect on the vasopressinergic system.en_US
dc.description.sponsorshipScientific Research Project Coordination Unit of Necmettin Erbakan University [143018001]en_US
dc.description.sponsorshipFunding for this study was provided by a grant from the Scientific Research Project Coordination Unit of Necmettin Erbakan University (Project no: 143018001). The authors wish to thank the patients and families who participated in this study. We gratefully acknowledge the assistance of Dr Umit Isik in laboratory collections.en_US
dc.identifier.doi10.1111/pcn.12415
dc.identifier.endpage447en_US
dc.identifier.issn1323-1316
dc.identifier.issn1440-1819
dc.identifier.issue10en_US
dc.identifier.pmid27283127en_US
dc.identifier.scopus2-s2.0-84989223370en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage442en_US
dc.identifier.urihttps://doi.org/10.1111/pcn.12415
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14015
dc.identifier.volume70en_US
dc.identifier.wosWOS:000385563800004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPsychiatry And Clinical Neurosciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApelin-13en_US
dc.subjectAttention-Deficit Hyperactivity Disorderen_US
dc.subjectChildrenen_US
dc.subjectPlasmaen_US
dc.subjectVasopressinen_US
dc.titleExploratory study to evaluate plasma vasopressin and apelin-13 levels in children with attention-deficit hyperactivity disorderen_US
dc.typeArticleen_US

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