The effect of rs9939609 FTO gene polymorphism on weight loss after laparoscopic sleeve gastrectomy

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dc.contributor.authorBalasar, Ozgur
dc.contributor.authorCakir, Tugrul
dc.contributor.authorErkal, Ozgur
dc.contributor.authorAslaner, Arif
dc.contributor.authorCekic, Bulent
dc.contributor.authorUyar, Mehmet
dc.contributor.authorBulbuller, Nurullah
dc.date.accessioned2024-02-23T13:43:52Z
dc.date.available2024-02-23T13:43:52Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractPurpose Remarkable differences in weight loss have been observed in obese patients undergoing laparoscopic sleeve gastrectomy (LSG). These high variations might be partly explained by genetic factors. The rs9939609 fat mass and obesity-associated gene (FTO) polymorphism has been implicated in the susceptibility of obesity. We aimed to explore the effects of the rs9939609 FTO gene polymorphism on weight loss among severely obese patients applying for LSG. Materials and methods All individuals were analyzed for the FTO rs9939609 gene polymorphism. A total of 74 morbid obese patients (20 male, 54 female) were operated. Body weight and body mass index (BMI) were measured at before LSG and after surgery at the sixth month. Results Twenty-eight patients (37.8 %) had genotype TT (wild-type allel), 36 patients (48.6 %) had genotype TA, and 10 patients (13.5 %) had genotype AA. In both wildtype group and mutant group, BMI and weight levels decreased at the sixth month after surgery. Percent of excess weight loss (EWL) at 6 months of follow-up was similar in both groups. There were no differences between the mutant and wild-type groups percent of EWL at the sixth month after applying LSG. Conclusion Our data showed that the rs9939609 FTO gene polymorphism is not a useful genetic test prior to LSG to help clinicians predicting the weight loss for severely obese patients in short-term follow-up.en_US
dc.description.sponsorshipAntalya Education and Research Hospital [81266704]en_US
dc.description.sponsorshipThis work was supported by Antalya Education and Research Hospital (Grant Number: 81266704).en_US
dc.identifier.doi10.1007/s00464-015-4169-y
dc.identifier.endpage125en_US
dc.identifier.issn0930-2794
dc.identifier.issn1432-2218
dc.identifier.issue1en_US
dc.identifier.pmid25801113en_US
dc.identifier.scopus2-s2.0-84955203421en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage121en_US
dc.identifier.urihttps://doi.org/10.1007/s00464-015-4169-y
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10956
dc.identifier.volume30en_US
dc.identifier.wosWOS:000369334600015en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofSurgical Endoscopy And Other Interventional Techniquesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRs9939609 Fto Gene Polymorphismen_US
dc.subjectLaparoscopic Sleeve Gastrectomyen_US
dc.subjectWeight Lossen_US
dc.titleThe effect of rs9939609 FTO gene polymorphism on weight loss after laparoscopic sleeve gastrectomyen_US
dc.typeArticleen_US

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