Prognostic Value of Neutrophil to Lymphocyte Ratio in Patients with Acute Pulmonary Embolism: A Restrospective Study

Basit Öğe Kaydı
dc.contributor.authorKayrak, Mehmet
dc.contributor.authorErdogan, Halil Ibrahim
dc.contributor.authorSolak, Yalcin
dc.contributor.authorAkll, Hakan
dc.contributor.authorGul, Enes Elvin
dc.contributor.authorYldrm, Oguzhan
dc.contributor.authorErer, Murat
dc.date.accessioned2024-02-23T14:03:02Z
dc.date.available2024-02-23T14:03:02Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractBackground Acute pulmonary embolism (PE) is a serious clinical condition characterised by a high mortality rate. Previous studies showed that leukocytosis was associated with recurrences of venous thromboemboli, major bleeding and increased mortality. The aim of the present study was to investigate the prognostic value of neutrophil to lymphocyte ratio (NLR) in patients with acute PE during short term follow-up. Method A total of 640 patients were screened by 126 code of ICD-9 and 359 patients were included as cases of confirmed acute PE. Admission blood counts and clinical data were obtained from medical charts. The predictors of 30-day mortality were examined. Results Fifty-one out of 359 patients (14.2%) included in the study died during 30 days follow-up. In multivariate Cox regression analysis systolic blood pressure (HR:0.97 (0.94-0.99 CI95%), p = 0.019), diabetes mellitus (HR:3.3 (1.30-8.39 CI95%), p = 0.012), CK-MB(HR:1.03 (1.01-1.06 CI95%), p = 0.024) and NLR (HR:1.03 (1.01-1.06 CI95%), p = 0.008) were predictors of 30-day mortality. An optimal cut-off value of NLR was determined as 9.2 by using ROC curve. Hazards ratio of NLR > 9.2 was found to be 3.60 (1.44-9.18 CI95%, p = 0.006). NLR > 9.2 had a sensitivity, specificity, negative predictive value, and positive predictive value of 68.6%, 80.5%, 93.9% and 36.5%, respectively. Conclusion NLR on hospital admission may be a predictor of 30-day mortality in acute PE. Since complete blood count is a part of the routine laboratory investigation in the most hospitalised patients use and preliminary promising results of this study, NLR should be investigated in future prospective randomised trials regarding prognostic value in acute PE.en_US
dc.identifier.doi10.1016/j.hlc.2013.06.004
dc.identifier.endpage62en_US
dc.identifier.issn1443-9506
dc.identifier.issn1444-2892
dc.identifier.issue1en_US
dc.identifier.pmid23856365en_US
dc.identifier.scopus2-s2.0-84891830092en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage56en_US
dc.identifier.urihttps://doi.org/10.1016/j.hlc.2013.06.004
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11944
dc.identifier.volume23en_US
dc.identifier.wosWOS:000330486500009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofHeart Lung And Circulationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPulmonary Embolismen_US
dc.subjectLymphocytesen_US
dc.subjectWhite Blood Cellsen_US
dc.titlePrognostic Value of Neutrophil to Lymphocyte Ratio in Patients with Acute Pulmonary Embolism: A Restrospective Studyen_US
dc.typeArticleen_US

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