Protective effect of MitoTEMPO against cardiac dysfunction caused by ischemia-reperfusion: MCAO stroke model study

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dc.contributor.authorAkkoca, Ahmet
dc.contributor.authorBuyukakilli, Belgin
dc.contributor.authorBalli, Ebru
dc.contributor.authorGultekin, Burcu
dc.contributor.authorOzbay, Erkan
dc.contributor.authorDemirbag, Hatice Oruc
dc.contributor.authorTurkseven, Cagatay Han
dc.date.accessioned2024-02-23T14:17:11Z
dc.date.available2024-02-23T14:17:11Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractPurposeNeurological impairments are the leading cause of post-stroke mortality, while stroke-related cardiovascular diseases rank second in significance. This study investigates the potential protective effects of MitoTEMPO (2,2,6,6-tetramethyl-4-[[2-(triphenylphosphonio) acetyl] amino]-1-piperidinyloxy, monochloride, monohydrate), a mitochondria-specific antioxidant, against cardiac and neurological complications following stroke. The objective is to assess whether MitoTEMPO can be utilized as a protective agent for individuals with a high risk of stroke.Materials and methodsSeventeen-week-old male Wistar Albino rats were randomly assigned to three groups: SHAM, ischemia-reperfusion and MitoTEMPO + ischemia-reperfusion (MitoTEMPO injection 0.7 mg/kg/day for 14 days). The SHAM group underwent a sham operation, while the ischemia-reperfusion group underwent 1-h middle cerebral artery occlusion followed by three days of reperfusion. Afterwards, noninvasive thoracic electrical bioimpedance and electrocardiography measurements were taken, and sample collection was performed for histological and biochemical examinations.ResultsOur thoracic electrical bioimpedance and electrocardiography findings demonstrated that MitoTEMPO exhibited a protective effect on most parameters affected by ischemia-reperfusion compared to the SHAM group. Furthermore, our biochemical and histological data revealed a significant protective effect of MitoTEMPO against oxidative damage.ConclusionsThe findings suggest that both ischemia-reperfusion-induced cardiovascular abnormalities and the protective effect of MitoTEMPO may involve G-protein coupled receptor-mediated signaling mechanisms. This study was conducted with limitations including a single gender, a uniform age group, a specific stroke model limited to middle cerebral artery, and pre-scheduled only one ischemia-reperfusion period. In future studies, addressing these limitations may enable the implementation of preventive measures for individuals at high risk of stroke.en_US
dc.description.sponsorshipscientific Research Projects Department of Mersin University [2021-2-tP3-4470]en_US
dc.description.sponsorshipThis work was supported by the scientific Research Projects Department of Mersin University under Grant Number 2021-2-tP3-4470.en_US
dc.identifier.doi10.1080/00207454.2023.2273768
dc.identifier.issn0020-7454
dc.identifier.issn1563-5279
dc.identifier.pmid37862003en_US
dc.identifier.scopus2-s2.0-85174596038en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1080/00207454.2023.2273768
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12974
dc.identifier.wosWOS:001088349000001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofInternational Journal Of Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCardiovascular Diseaseen_US
dc.subjectIschemic Strokeen_US
dc.subjectMiddle Cerebral Artery Occlusionen_US
dc.titleProtective effect of MitoTEMPO against cardiac dysfunction caused by ischemia-reperfusion: MCAO stroke model studyen_US
dc.typeArticleen_US

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