Arterial Stiffness, Carotid Intima-Media Thickness, Endocan, and A Disintegrin and Metalloproteinase With Thrombospondin Type I Motif 9 Levels and Their Relationship With Disease Activity in Patients With Acromegaly With and Without Cardiovascular Risk Factors

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dc.contributor.authorCan, Mustafa
dc.contributor.authorKocabas, Muhammet
dc.contributor.authorKarakose, Melia
dc.contributor.authorYerlikaya, Fatma Humeyra
dc.contributor.authorAlsancak, Yakup
dc.contributor.authorTurkmen, Kultigin
dc.contributor.authorKulaksizoglu, Mustafa
dc.date.accessioned2024-02-23T14:02:52Z
dc.date.available2024-02-23T14:02:52Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractObjective: Cardiovascular complications such as cardiomyopathy and endothelial dysfunction, which are frequently seen in patients with acromegaly, are among the most important causes of morbidity and mortality. In this study, we aimed to investigate arterial stiffness, carotid intima-media thickness, endocan level, and A disintegrin and metalloproteinase with thrombospondin type I motif 9 level and their relationship with disease activity in patients with acromegaly with and without cardiovascular risk factors. Methods: A total of 60 patients with acromegaly-25 with active disease, 26 with well-controlled disease, and 9 with newly diagnosed disease-and 60 age-, sex-, and body mass index (BMI)-matched healthy control subjects were enrolled in this study. All the subjects' height, weight, BMI, systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting plasma glucose (FPG) level, insulin, hemoglobin A1C (HbA1C), C-reactive protein, lipid, endocan, A disintegrin and metalloproteinase with thrombospondin type I motif 9 levels, pulse wave velocity (PWV), and carotid intima-media thickness were measured. Results: The SBP, DBP, FPG level, HbA1C level, and PWV of the acromegaly group were higher than those of the control group. In patients with acromegaly with cardiovascular disease (CVD) risk factors, the PWV was higher than that in the control group, and in patients with acromegaly without CVD risk factors, the PWV was similar to that in the control group. In a correlation analysis, a positive correlation was found between PWV and age, BMI, SBP, DBP, FPG level, and HbA1C level in the acromegaly group. Conclusion: In our study, we found that arterial stiffness increased in patients with acromegaly with CVD risk factors and that increased arterial stiffness was associated with hemodynamic (SBP and DBP) and metabolic (BMI, FPG level, and HbA1C level) parameters. (c) 2021 AACE. Published by Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipscientific research projects of Necmettin Erbakan University [201218016]en_US
dc.description.sponsorshipOur study was financially supported by the scientific research projects of Necmettin Erbakan University (project number: 201218016).en_US
dc.identifier.doi10.1016/j.eprac.2021.11.084
dc.identifier.endpage303en_US
dc.identifier.issn1530-891X
dc.identifier.issn1934-2403
dc.identifier.issue3en_US
dc.identifier.pmid34843972en_US
dc.identifier.scopus2-s2.0-85123237888en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage298en_US
dc.identifier.urihttps://doi.org/10.1016/j.eprac.2021.11.084
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11865
dc.identifier.volume28en_US
dc.identifier.wosWOS:000881180700010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Incen_US
dc.relation.ispartofEndocrine Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcromegalyen_US
dc.subjectArterial Stiffnessen_US
dc.subjectCarotid Intima-Media Thicknessen_US
dc.subjectEndocanen_US
dc.subjectAdamts9en_US
dc.titleArterial Stiffness, Carotid Intima-Media Thickness, Endocan, and A Disintegrin and Metalloproteinase With Thrombospondin Type I Motif 9 Levels and Their Relationship With Disease Activity in Patients With Acromegaly With and Without Cardiovascular Risk Factorsen_US
dc.typeArticleen_US

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