Inflammatory bowel disease in Turkish children

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dc.contributor.authorCakir, Murat
dc.contributor.authorUnal, Fatih
dc.contributor.authorDinler, Gonul
dc.contributor.authorBaran, Masallah
dc.contributor.authorYuksekkaya, Hasan Ali
dc.contributor.authorTumgor, Gokhan
dc.contributor.authorKasirga, Erhun
dc.date.accessioned2024-02-23T13:59:56Z
dc.date.available2024-02-23T13:59:56Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractThis study was undertaken to evaluate demographics, clinical manifestations, laboratory findings and outcomes of children with inflammatory bowel disease (IBD) in Turkey. We analyzed the medical records of 127 children diagnosed with IBD (under 18 years old) between January 2004 and January 2012 in 8 pediatric gastroenterology centers. Of the 127 patients, 90 (70.9%) suffered from ulcerative colitis (UC), 29 (22.8%) from Crohn's disease (CD), and 8 (6.3%) from IBD unclassified. The mean age of the 127 patients was 11.6 +/- 4.1 years, and 11.8% of the patients were below 5 years old. Of the patients, 49.6% were male, and males were more predominant in patients with CD than in those with UC (72.4% vs. 42.2%, P=0.008; a male/female ratio of 2.62 in CD, P=0.0016). Approximately one fifth of the patients had extra-intestinal manifestations and 13.3% of the patients had associated diseases. Extraintestinal manifestations and associated diseases were more common in early onset disease [P=0.017, odds ratio (OR)=4.02; P=0.03, OR=4.1]. Of the patients, 15% had normal laboratory parameters including anemia, high platelet count, hypoalbuminemia, hypoferritinemia, and high sedimentation rate. Area under receiver operation characteristics was used to predict pancolitis in patients with UC. The values of C-reactive protein, sedimentation rate and pediatric ulcerative colitis activity were 0.61 (P=0.06), 0.66 (P=0.01) and 0.76 (P=0.0001), respectively. Four (4.4%) patients with UC underwent colectomy, and finally two (1.5%, 95% confidence interval: 0-3.7%) patients died from primary disease or complications. IBD is an increasing clinical entity in Turkey. Features of IBD are similar to those in other populations, but prospective multicenter studies are needed to analyze the true incidence of IBD in Turkish children.en_US
dc.identifier.doi10.1007/s12519-015-0042-2
dc.identifier.endpage337en_US
dc.identifier.issn1708-8569
dc.identifier.issn1867-0687
dc.identifier.issue4en_US
dc.identifier.pmid26454438en_US
dc.identifier.scopus2-s2.0-84943644146en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage331en_US
dc.identifier.urihttps://doi.org/10.1007/s12519-015-0042-2
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11381
dc.identifier.volume11en_US
dc.identifier.wosWOS:000362690900007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherZhejiang Univ Sch Medicineen_US
dc.relation.ispartofWorld Journal Of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAssociated Diseasesen_US
dc.subjectCrohn's Diseaseen_US
dc.subjectInflammatory Bowel Diseaseen_US
dc.subjectOutcomeen_US
dc.subjectUlcerative Colitisen_US
dc.titleInflammatory bowel disease in Turkish childrenen_US
dc.typeArticleen_US

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