The effects of orchiectomy and steroid on fertility in experimental testicular atrophy

Basit Öğe Kaydı
dc.contributor.authorYurtcu, Muslim
dc.contributor.authorKozacioglu, Sumeyye
dc.contributor.authorKocabas, Rahim
dc.date.accessioned2024-02-23T14:44:42Z
dc.date.available2024-02-23T14:44:42Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractObjective: Despite our understanding of Sertoli cell function and the state of spermatogenesis, the underlying mechanisms remain unclear. This study was conducted to compare the effects of orchiectomy and steroid treatment on fertility in testicular atrophy occurring after testic-ular torsion.Methods: Thirty-three rats were divided into four groups. The atrophy, orchiectomy, and atrophy-steroid groups each contained nine rats, while the control group contained six. The left testes were rotated 720o, and atrophy was observed. In the atrophy-steroid rats, orchiectomy was performed after atrophy, and 1 mg/kg steroid was injected. Each male rat was housed with five female rats for 6 days. The fertility of the male rats was evaluated based on the pregnancy of the female rats. Left and right orchiectomies were performed to determine the tissue Johnsen score (JS) and the serum inhibin B (IB) level.Results: JS values were significantly lower in the atrophy, orchiectomy, and atrophy-steroid groups than in the control group (p<0.05), while no significant difference was observed in JS between the atrophy and orchiectomy groups (p>0.05). Similarly, no significant differences in IB level or fertility percentage were found between the atrophy and orchiectomy rats (p>0.05).Conclusion: In unilateral testicular atrophy, which can occur in the prepubertal period due to various causes, orchiectomy does not appear to benefit fertility, as indicated by IB, JS, and the fertility percentage.en_US
dc.identifier.doi10.5653/cerm.2022.05750
dc.identifier.endpage98en_US
dc.identifier.issn2233-8233
dc.identifier.issn2233-8241
dc.identifier.issue2en_US
dc.identifier.pmid37258102en_US
dc.identifier.scopus2-s2.0-85163047044en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage94en_US
dc.identifier.urihttps://doi.org/10.5653/cerm.2022.05750
dc.identifier.urihttps://hdl.handle.net/20.500.12452/17066
dc.identifier.volume50en_US
dc.identifier.wosWOS:001007406100004en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKorean Soc Reproductive Medicineen_US
dc.relation.ispartofClinical And Experimental Reproductive Medicine-Cermen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAtrophyen_US
dc.subjectFertilityen_US
dc.subjectOrchiectomyen_US
dc.subjectSteroidsen_US
dc.subjectTestisen_US
dc.titleThe effects of orchiectomy and steroid on fertility in experimental testicular atrophyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu