Evaluation from a different perspective of 10-year results of infertile males with Y chromosome AZFc microdeletions compared with a control group

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dc.contributor.authorSalvarci, Ahmet
dc.contributor.authorGurbuz, Ali Sami
dc.contributor.authorBalasar, Mehmet
dc.date.accessioned2024-02-23T14:24:01Z
dc.date.available2024-02-23T14:24:01Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractAZFc microdeletions will be evaluated upon being divided into partial and complete subgroups. The association of deletions with reactive oxidative stress (ROS) and sperm DNA fragmentation (SDFI) and the impact of their coexistence on fertility starting from the pregnancy process until live birth will be presented. Semen analyses, microbiological results, hormones, ROS and sperm TUNEL tests were checked. Preimplantation genetic testing (PGT) was planned for relevant patients. Intracytoplasmic sperm injection (ICSI) was applied. Their embryo fragmentation was monitored via time lapse. Their results were compared with those with no AZF deletion and no other genetic problems. Azoospermia rate was 71.5%, m-TESE success rate was 25%, pregnancy rate was 26% and live child rate was 2.2%. No difference was detected between the partial and total groups in terms of ROS and SDFI rates and no difference was identified with the control group. Better results were obtained in terms of live child rate in patients with partial AZFc and low ROS/SDFI. Spermatozoon was retrieved in AZFc deletions and pregnancy, and live child was identified. No AZFc impact was observed on ROS and SDFI in the results compared with the control groups in terms of their coexistence.en_US
dc.identifier.doi10.1111/and.13572
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue6en_US
dc.identifier.pmid32237082en_US
dc.identifier.scopus2-s2.0-85082577208en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1111/and.13572
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13782
dc.identifier.volume52en_US
dc.identifier.wosWOS:000523359500001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAndrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAzfcen_US
dc.subjectDeliveryen_US
dc.subjectPregnancy Outcomesen_US
dc.subjectY Chromosome Deletionen_US
dc.titleEvaluation from a different perspective of 10-year results of infertile males with Y chromosome AZFc microdeletions compared with a control groupen_US
dc.typeArticleen_US

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