May Neutrophil Gelatinase-Associated Lipocalin (NGAL) Level Predict Mortality in Patients with Hepatocellular Carcinoma (HCC)?

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dc.contributor.authorDertli, Ramazan
dc.contributor.authorBiyik, Murat
dc.contributor.authorYolacan, Ramazan
dc.contributor.authorKarakarcayildiz, Ahmet
dc.contributor.authorKeskin, Muharrem
dc.contributor.authorKayar, Yusuf
dc.contributor.authorAsil, Mehmet
dc.date.accessioned2024-02-23T13:59:45Z
dc.date.available2024-02-23T13:59:45Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractPurpose Hepatocellular carcinoma (HCC) ranks fifth among the common cancers worldwide. Hepatocarcinogenesis is a multiple-phases process, which involves changes in cellular genomes including high cell proliferation.In this study, we aimed to evaluate the relationship of NGAL level at the time of diagnosis with mortality in patients diagnosed with HCC. Material and Methods A total of 35 patients who developed HCC on the ground of HBV(+) and 30 healthy subjects were included in the study. Barcelona Clinic Liver Cancer (BCLC), Okuda staging system, and Milan criteria were used for staging of the patients with HCC. Results The mean age of all patients was 59.54 +/- 11.57 years. Seventeen (48.6%) HCC patients died during 1-year follow-up. Survival of the patients who met the Milan criteria was longer (log-rank (Mantel-Cox) test, chi 2 = 5.353,p= 0.021). Kaplan-Meier curve was drawn for NGAL cut-off value, mortality was found to be higher in patients with a NGAL level higher than 217.50 (log-rank (Mantel-Cox) test, chi 2 = 15.540,p< 0.001). Conclusion In this study, we found that high levels of NGAL at the time of diagnosis were associated with poor prognosis in HCC patients.en_US
dc.identifier.doi10.1007/s12029-019-00323-9
dc.identifier.endpage938en_US
dc.identifier.issn1941-6628
dc.identifier.issn1941-6636
dc.identifier.issue3en_US
dc.identifier.pmid31729643en_US
dc.identifier.scopus2-s2.0-85075373917en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage932en_US
dc.identifier.urihttps://doi.org/10.1007/s12029-019-00323-9
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11309
dc.identifier.volume51en_US
dc.identifier.wosWOS:000556028900029en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Gastrointestinal Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOrdsen_US
dc.subjectHepatocellular Carcinomaen_US
dc.subjectLipocalin-2en_US
dc.subjectNeutrophil Gelatinase-Associated Lipocalinen_US
dc.titleMay Neutrophil Gelatinase-Associated Lipocalin (NGAL) Level Predict Mortality in Patients with Hepatocellular Carcinoma (HCC)?en_US
dc.typeArticleen_US

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