The impact of COVID-19 on familial Mediterranean fever: a nationwide study

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dc.contributor.authorGunendi, Zafer
dc.contributor.authorYurdakul, Fatma Gul
dc.contributor.authorBodur, Hatice
dc.contributor.authorCengiz, Ahmet Kivanc
dc.contributor.authorUcar, Ulku
dc.contributor.authorCay, Hasan Fatih
dc.contributor.authorSen, Nesrin
dc.date.accessioned2024-02-23T13:43:43Z
dc.date.available2024-02-23T13:43:43Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractThe study aimed to evaluate the impact of the coronavirus disease 2019 (COVID-19) in patients with familial Mediterranean fever (FMF) and to assess the relationships between FMF characteristics and severe COVID-19 outcomes such as hospitalization. The study was planned within a national network of 21 different centers. Demographics, FMF-related clinical and genetic characteristics, and COVID-19 outcomes were obtained. A total of 822 patients with FMF (mean age of 36 years) were included in the study. Fifty-nine of them (7%) had a COVID-19 diagnosis confirmed by real-time PCR test or chest CT findings. Most FMF patients with COVID-19 (58) had mild and moderate disease activity. All patients were on colchicine treatment. However, 8 of them (13.6%) were not compliant with colchicine use and 9 of them (15.3%) were colchicine resistant. Twelve FMF patients with COVID-19 were hospitalized. There were 4 patients requiring oxygen support. COVID-19 related complications were observed in 2 patients (1 thromboembolism, 1 acute respiratory distress syndrome). Hospitalized COVID-19 patients with FMF were older than non-hospitalized patients (median ages: 51 and 31 years, respectively; p: 0.002). Other FMF-related characteristics were similar between the groups. FMF-related characteristics were not found to be associated with poor outcomes in COVID-19. Thus, FMF may not be a risk factor for poor COVID-19 outcomes.en_US
dc.identifier.doi10.1007/s00296-021-04892-6
dc.identifier.endpage1455en_US
dc.identifier.issn0172-8172
dc.identifier.issn1437-160X
dc.identifier.issue8en_US
dc.identifier.pmid34032894en_US
dc.identifier.scopus2-s2.0-85106463983en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1447en_US
dc.identifier.urihttps://doi.org/10.1007/s00296-021-04892-6
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10887
dc.identifier.volume41en_US
dc.identifier.wosWOS:000654089100002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofRheumatology Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCovid-19en_US
dc.subjectFamilial Mediterranean Feveren_US
dc.subjectRheumatic Diseasesen_US
dc.subjectColchicineen_US
dc.subjectHospitalizationen_US
dc.subjectPoor Outcomesen_US
dc.titleThe impact of COVID-19 on familial Mediterranean fever: a nationwide studyen_US
dc.typeArticleen_US

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