The investigation of circulating microRNAs associated with lipid metabolism in childhood obesity

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dc.contributor.authorCan, U.
dc.contributor.authorBuyukinan, M.
dc.contributor.authorYerlikaya, F. H.
dc.date.accessioned2024-02-23T14:24:17Z
dc.date.available2024-02-23T14:24:17Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractBackground: Childhood obesity is an increasing health challenge related to increased risk of chronic diseases. microRNAs (miRNAs) are noncoding short RNA molecules regulating multiple biological processes linked to obesity. Objectives: We aimed at evaluating the association between circulating miRNA levels and lipid metabolism in obese and non-obese children and adolescents. Methods: By constituting study group, 45 obese children and adolescents were recruited. To perform comparisons with study group, 41 lean controls were matched for age and sex. Using real-time quantitative PCR analysis, circulating miRNAs were evaluated in both groups. Results: Circulating miR-335 (P < 0.001), miR-143 (P = 0.001) and miR-758 (P = 0.006) in obese children were significantly lower than those of controls. However, circulating miR-27 (P = 0.032), miR-378 (P < 0.001) and miR-370 (P = 0.045) in obese children were significantly higher, compared with those of controls. In addition, circulating miR-33 in obese children was higher than those of controls, but no significant difference was present (P = 0.687). Conclusion: Our findings showed that a significant association is present between circulating miR-370, miR-33, miR-378, miR-27, miR-335, miR-143 and miR-758 values, and childhood obesity. Low levels of miR-335, miR-143 and miR-758, and high levels of miR-27, miR-378, miR-33 and miR-370 may have been responsible for elevated triglycerides and low-density lipoprotein (LDL-C) levels, and low level of high-density lipoprotein (HDL-C) in obese subjects. Therefore, miRNAs may be a good novel biomarker for childhood obesity.en_US
dc.description.sponsorshipKonya Education and Research Hospitalen_US
dc.description.sponsorshipThis study was financially supported by Konya Education and Research Hospital. All patients were examined by MB. Data analyses were performed by UC and FHY in the Department of Biochemistry in Meram Faculty of Medicine of Necmettin Erbakan University. Study design, data interpretation, literature search, generation of figures and editing the manuscript were performed by UC.en_US
dc.identifier.doi10.1111/ijpo.12050
dc.identifier.endpage234en_US
dc.identifier.issn2047-6310
dc.identifier.issn2047-6302
dc.identifier.issue3en_US
dc.identifier.pmid26223376en_US
dc.identifier.scopus2-s2.0-84964763144en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage228en_US
dc.identifier.urihttps://doi.org/10.1111/ijpo.12050
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13888
dc.identifier.volume11en_US
dc.identifier.wosWOS:000375780200010en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPediatric Obesityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdiponectin And Interleukin-6en_US
dc.subjectLipid Metabolismen_US
dc.subjectMicrornasen_US
dc.subjectObesityen_US
dc.titleThe investigation of circulating microRNAs associated with lipid metabolism in childhood obesityen_US
dc.typeArticleen_US

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