Can YKL-40 be an Inflammatory Biomarker in Vitamin D Deficiency?

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dc.contributor.authorCan, Ummugulsum
dc.contributor.authorUysal, Saliha
dc.contributor.authorUgur, Ayse Ruveyda
dc.contributor.authorToker, Aysun
dc.contributor.authorAslan, Uysaler
dc.contributor.authorHidayetoglu, Bahauddin Taha
dc.date.accessioned2024-02-23T14:16:38Z
dc.date.available2024-02-23T14:16:38Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractVitamin D deficiency is associated with several non-homeostatic conditions and/or diseases like inflammation, atherosclerosis, cardiovascular disease and mortality. YKL-40 is a glycoprotein, secreted by macrophages, neutrophils and different cell types and it is also associated with inflammation and pathological tissue remodeling. In this study, we aimed to evaluate relationship between the proinflammatory biomarkers YKL-40 and hs-CRP levels and vitamin D deficiency. Our study group includes 45 subjects with vitamin D deficiency (Group 1) (20 M, 25 F; mean age 37.72 +/- 7.70 years) and 40 age and sex-matched healthy subjects with normal serum levels of vitamin D (Group 2) (19 M, 21 F; mean age 39.26 +/- 7.41 years). Plasma 25 (OH) vitamin D levels were measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS) method. Plasma YKL-40 analysis was performed by ELISA. Serum hs-CRP levels were measured by nephelometric method. Plasma vitamin D levels below 20 ng/mL were accepted as vitamin D deficiency. Although we could not find any significant differences by means of serum hs-CRP levels between Group 1 and Group 2 (2.21 (0.27-11.70); 1.79 (0.16-9.85) mg/L, p = 0.247), plasma YKL-40 levels were significantly higher in group 1 than group2 (70.47 (17.84-198.50); 47.14 (4.80-135.48) ng/mL, p = 0.047). In literature, vitamin D deficiency is associated with inflammation. In our study, we found similar hs-CRP levels between groups and higher YKL-40 levels in group 1. Vitamin D deficiency may be related to high YKL-40 levels in terms of causing chronic inflammation.en_US
dc.description.sponsorshipKonya Education and Research Hospitalen_US
dc.description.sponsorshipThis study was financially supported by Konya Education and Research Hospital. No financial or other potential conflicts of interest exist.en_US
dc.identifier.doi10.1024/0300-9831/a000545
dc.identifier.endpage313en_US
dc.identifier.issn0300-9831
dc.identifier.issn1664-2821
dc.identifier.issue5.Hazen_US
dc.identifier.pmid30806610en_US
dc.identifier.scopus2-s2.0-85075503925en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage309en_US
dc.identifier.urihttps://doi.org/10.1024/0300-9831/a000545
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12745
dc.identifier.volume89en_US
dc.identifier.wosWOS:000498911300011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerlag Hans Huberen_US
dc.relation.ispartofInternational Journal For Vitamin And Nutrition Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVitamin D Deficiencyen_US
dc.subjectYkl-40en_US
dc.subjectInflammationen_US
dc.titleCan YKL-40 be an Inflammatory Biomarker in Vitamin D Deficiency?en_US
dc.typeArticleen_US

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