The association of decreased testosterone with atherosclerosis and inflammation in male predialysis patients with chronic kidney disease

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dc.contributor.authorAydemir, Harun
dc.contributor.authorGuney, Ibrahim
dc.contributor.authorDuran, Cevdet
dc.contributor.authorGencer, Vedat
dc.contributor.authorAkbayrak, Sahabettin
dc.contributor.authorKurku, Huseyin
dc.contributor.authorAkgul, Yavuz Sultan Selim
dc.date.accessioned2024-02-23T14:02:08Z
dc.date.available2024-02-23T14:02:08Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractPurpose: To investigate the frequency of hypogonadism and its relationship to inflammation and carotid intima-media thickness (CIMT) in male patients with predialysis chronic kidney disease (CKD). Methods: A total of 105 patients with CKD, 55 (52.4%) as stage 3, 33 (31.4%) as stage 4 and 17 (16.2%) as stage 5, were enrolled into the study. Total testosterone (TT) and free testosterone (FT), interleukin 6 (IL-6), C-reactive protein (CRP) levels, and CIMT were measured. Results: According to TT and FT, hypogonadism was detected in 18 (17.1%) and 22 (20.9%) patients, respectively. There was no difference in terms of TT and FT, CIMT, CRP and IL-6 between the stages of CKD. According to TT, the patients with hypogonadism had significantly higher CRP and high-density lipoprotein cholesterol (HDL-cholesterol) levels (p=0.004 and p=0.005, respectively). There was no significant difference in other parameters. According to FT, the patients with hypogonadism had significantly higher CRP (p=0.017), and TT were negatively correlated with body mass index (BMI), waist circumference (WC), hip circumference, and CRP levels. FT was negatively correlated with age, waist circumference, systolic blood pressure, diastolic blood pressure (DBP) and CRP. Conclusions: The frequency of hypogonadism was found around 17-21% among the patients with CKD. Despite similar IL-6 and CIMT levels, CRP was found to be higher in the patients with hypogonadism. We consider that further studies with larger populations are needed to elucidate the entity. (C) 2020 Sociedad Espanola de Arteriosclerosis. Published by Elsevier Espana, S.L.U. All rights reserved.en_US
dc.description.sponsorshipKonya Training and Research Hospitalen_US
dc.description.sponsorshipThis study was funded by the research fund of Konya Training and Research Hospital.en_US
dc.identifier.doi10.1016/j.arteri.2020.01.002
dc.identifier.endpage143en_US
dc.identifier.issn0214-9168
dc.identifier.issn1578-1879
dc.identifier.issue4en_US
dc.identifier.pmid32291192en_US
dc.identifier.scopus2-s2.0-85083005716en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage135en_US
dc.identifier.urihttps://doi.org/10.1016/j.arteri.2020.01.002
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11606
dc.identifier.volume32en_US
dc.identifier.wosWOS:000553044900001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofClinica E Investigacion En Arteriosclerosisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntherosclerosisen_US
dc.subjectHypogonadismen_US
dc.subjectInflammationen_US
dc.subjectChronic Kidney Diseaseen_US
dc.subjectPredialysisen_US
dc.titleThe association of decreased testosterone with atherosclerosis and inflammation in male predialysis patients with chronic kidney diseaseen_US
dc.typeArticleen_US

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