The Effect of Soluble TREM-1 in Idiopathic Granulomatous Mastitis

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dc.contributor.authorAtes, Dervis
dc.contributor.authorDoner, Hulusi Cem
dc.contributor.authorKurban, Sevil
dc.contributor.authorKoksal, Hande
dc.date.accessioned2024-02-23T14:20:16Z
dc.date.available2024-02-23T14:20:16Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractBackground and objectives: The aim of this study is to investigate the effect of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in idiopathic granulomatous mastitis (IGM). Methods: This case-control study was conducted in Saglik Bilimleri and Necmettin Erbakan Universities. Sixty patients with IGM diagnosis (Group P) and 25 healthy females as control group (Group C) were included. Group P was divided into two subgroups according to the activity of disease: patients with active lesion (Group P-A), and patients without any symptoms, in remission (Group P-R). The ELISA method was used to measure sTREM-1 level. Results: Group P's sTREM-1 were higher than Group C (p < .0001). The difference between sTREM-1 levels of Groups P-A, P-R and C was significant statistically (p < .0001). Group P-A's sTREM-1 levels were higher than Group C (p < .0001). Also, sTREM-1 levels of Group P-R were higher than Group C (p = .006). When sTREM-1 levels of patients receiving steroid therapy and did not in Group P-R were analyzed, the sTREM-1 levels of the patients not receiving steroid treatment were found to be statistically higher than Group C (p = .002). Although the sTREM-1 levels of the patients who did not receive steroid therapy were higher than those who received steroid therapy, the difference was not statistically significant (p > .05). Conclusion: We concluded that the detected high sTREM-1 levels contributed to inflammation in IGM. In particular, blockade of TREM may be a promising treatment option in resistant or multiple recurrent patients.en_US
dc.description.sponsorshipKonya Education and Research Hospitalen_US
dc.description.sponsorshipThe study was supported by the Konya Education and Research Hospital.en_US
dc.identifier.doi10.1080/08820139.2021.1879846
dc.identifier.endpage850en_US
dc.identifier.issn0882-0139
dc.identifier.issn1532-4311
dc.identifier.issue4en_US
dc.identifier.pmid33522329en_US
dc.identifier.scopus2-s2.0-85100260438en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage839en_US
dc.identifier.urihttps://doi.org/10.1080/08820139.2021.1879846
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13093
dc.identifier.volume51en_US
dc.identifier.wosWOS:000613376700001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofImmunological Investigationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIdiopathic Granulomatous Mastitisen_US
dc.subjectTriggering Receptor Expressed On Myeloid Cells-1en_US
dc.subjectEthiopathogenesisen_US
dc.titleThe Effect of Soluble TREM-1 in Idiopathic Granulomatous Mastitisen_US
dc.typeArticleen_US

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