Role of Melatonin Receptors in Hyperthermia-Induced Acute Seizure Model of Rats

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dc.contributor.authorMogulkoc, Rasim
dc.contributor.authorBaltaci, Abdulkerim Kasim
dc.contributor.authorAydin, Leyla
dc.date.accessioned2024-02-23T13:59:46Z
dc.date.available2024-02-23T13:59:46Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractMelatonin is a neurohormone that has anticonvulsant activity in different experimental seizure models including hyperthermic febrile seizure. However, the mechanisms of this effect are not clear at the receptor level. The aim of the study was to determine which melatonin receptors involve in the hyperthermic febrile seizure model. 22-30 days Wistar male rats were used, and in children, it corresponds to 1.5-2 years. Groups were performed as (1) control, (2) ethanol/saline, (3) DMSO, (4) melatonin (MT), (5) MT + luzindole (LUZ), (6) MT + K-185, (7) MT + prazosin (PRZ), (8) MT + LUZ + K-185, (9) MT + LUZ + PRZ, (10) MT + K-185 + PRZ, and (11) MT + LUZ + PRZ + K-185. The hyperthermic febrile seizure pattern was established by keeping the rats in 45 degrees C hot water, and the latency, duration, and severity of seizures were determined in all groups. MT, LUZ, K-185, and PRZ were given 15, 45, 15, and 30 min before the induction of seizure, respectively. It was observed that melatonin shortened the duration of seizure, reduced the severity, and did not affect latency and that these effects were not completely blocked by receptor antagonists when compared with control, ethanol/saline, and DMSO groups. In conclusion, the fact that the anticonvulsant effect of melatonin is not completely blocked by all melatonin receptor antagonists. We can conclude that a multimodal mechanism may be responsible for the effect of melatonin receptors alone on the anticonvulsant effect of melatonin. It will be useful to design new pharmacological studies to make the subject clear.en_US
dc.description.sponsorshipSelcuk University, Scientific Research Council [16401130]en_US
dc.description.sponsorshipThis study was supported by a grant from the Selcuk University, Scientific Research Council (grant number is 16401130). Authors would like to thank Begum Aydin Gazi University Faculty of Medicine helps during experiments.en_US
dc.identifier.doi10.1007/s12031-019-01392-y
dc.identifier.endpage642en_US
dc.identifier.issn0895-8696
dc.identifier.issn1559-1166
dc.identifier.issue4en_US
dc.identifier.pmid31418115en_US
dc.identifier.scopus2-s2.0-85071047190en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage636en_US
dc.identifier.urihttps://doi.org/10.1007/s12031-019-01392-y
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11321
dc.identifier.volume69en_US
dc.identifier.wosWOS:000496661000015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofJournal Of Molecular Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFebrile Seizureen_US
dc.subjectMelatoninen_US
dc.subjectLuzindoleen_US
dc.subjectK-185en_US
dc.subjectPrazosinen_US
dc.subjectRaten_US
dc.titleRole of Melatonin Receptors in Hyperthermia-Induced Acute Seizure Model of Ratsen_US
dc.typeArticleen_US

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