Platelet-to-lymphocyte ratio better predicts inflammation than neutrophil-to-lymphocyte ratio in end-stage renal disease patients

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dc.contributor.authorTurkmen, Kultigin
dc.contributor.authorErdur, Fatih Mehmet
dc.contributor.authorOzcicek, Fatih
dc.contributor.authorOzcicek, Adalet
dc.contributor.authorAkbas, Emin Murat
dc.contributor.authorOzbicer, Aysu
dc.contributor.authorDemirtas, Levent
dc.date.accessioned2024-02-23T14:24:14Z
dc.date.available2024-02-23T14:24:14Z
dc.date.issued2013
dc.departmentNEÜen_US
dc.description.abstractNeutrophil-to-lymphocyte ratio (NLR) was introduced as a potential marker to determine inflammation in end-stage renal disease (ESRD) patients. Recently, platelet-to-lymphocyte ratio (PLR) and NLR were found to positively correlated with inflammatory markers including tumor necrosis factor- (TNF-) and interleukin (IL)-6 in cardiac and noncardiac patients. Data regarding PLR and its association with inflammation are lacking in hemodialysis (HD) and peritoneal dialysis (PD) patients. Hence, we aimed to determine the relationship between PLR, NLR, and inflammation in ESRD patients. This was a cross-sectional study involving 62 ESRD patients (29 females, 33 males; mean age, 49.6 +/- 14.6 years) receiving PD or HD for 6 months in the Dialysis Unit of Necmettin Erbakan University. PLR, NLR, C-reactive protein, TNF-, IL-6 levels were measured. PLR, NLR, serum high sensitive C-reactive protein, IL-6, and TNF- levels were significantly higher in PD patients when compared with HD patients. ESRD patients with PLR140 had significantly higher NLR, IL-6, and TNF- levels when compared to patients with PLR<139. In the bivariate correlation analysis, PLR was positively correlated with NLR, IL-6, and TNF- in this population. When we compared the association of PLR and NLR with IL-6 (r=0.371, P=0.003 vs. r=0.263, P=0.04, respectively) and TNF- (r=0.334, P=0.008 vs. r=0.273, P=0.032, respectively), PLR was found to be superior to NLR in terms of inflammation in ESRD patients. Simple calculation of PLR can predict inflammation better than NLR in ESRD patients.en_US
dc.identifier.doi10.1111/hdi.12040
dc.identifier.endpage396en_US
dc.identifier.issn1492-7535
dc.identifier.issn1542-4758
dc.identifier.issue3en_US
dc.identifier.pmid23522328en_US
dc.identifier.scopus2-s2.0-84879604314en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage391en_US
dc.identifier.urihttps://doi.org/10.1111/hdi.12040
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13852
dc.identifier.volume17en_US
dc.identifier.wosWOS:000320936600009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofHemodialysis Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEnd-Stage Renal Diseaseen_US
dc.subjectInflammationen_US
dc.subjectPlatelet-To-Lymphocyte Ratioen_US
dc.subjectNeutrophil-To-Lymphocyte Ratioen_US
dc.titlePlatelet-to-lymphocyte ratio better predicts inflammation than neutrophil-to-lymphocyte ratio in end-stage renal disease patientsen_US
dc.typeArticleen_US

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