Shedding light on the biological and chemical fingerprints of three Achillea species (A-biebersteinii, A-millefolium and A-teretifolia)

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dc.contributor.authorZengin, Gokhan
dc.contributor.authorAktumsek, Abdurrahman
dc.contributor.authorCeylan, Ramazan
dc.contributor.authorUysal, Sengul
dc.contributor.authorMocan, Andrei
dc.contributor.authorGuler, Gokalp Ozmen
dc.contributor.authorMahomoodally, M. Fawzi
dc.date.accessioned2024-02-23T14:16:45Z
dc.date.available2024-02-23T14:16:45Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractRepresentatives of the Achillea genus are widely used as foods or nutraceuticals. Considering the increasing demand for herbal dietary supplements with health promoting effects, the objective of this research was to evaluate the biological and chemical profiles of different extracts (ethyl acetate, methanol and water) obtained from three Achillea species (A. biebersteinii, A. millefolium and A. teretifolia). The antioxidant (free radical scavenging (DPPH and ABTS), reducing power (CUPRAC and FRAP), metal chelating and phosphomolybdenum), enzyme inhibitory (anti-cholinesterase, anti-tyrosinase, anti-amylase and anti-glucosidase) and antimicrobial (antibacterial and antifungal) effects were assessed to investigate their biological profiles. Moreover, the total phenolic and flavonoid contents were determined and LC-MS analysis was performed for the chemical profile of the investigated extracts. The LC-MS analysis revealed the presence of several caffeoylquinic acids in these extracts. Generally, the methanol and water extracts exhibited stronger antioxidant abilities, which correlated with the higher levels of phenolic compounds when compared to the ethyl acetate extracts. In addition, the best antimicrobial activities were obtained for the ethyl acetate and methanolic extracts. However, the ethyl acetate extract had remarkable enzyme inhibitory potential. On the basis of our results, Achillea species may be promoted as promising sources of natural agents and used for the development of nutraceuticals or functional food ingredients.en_US
dc.description.sponsorshipFoundation of Necmettin Erbakan University (BAP) [161710001]; Serbian Ministry of Education, Science and Technological development [173032]en_US
dc.description.sponsorshipThe authors are grateful to Assoc. Prof. Paraskev Nedialkov and Assist. Prof. Dimitrina Zheleva-Dimitrova, the Department of Pharmacognosy, the Faculty of Pharmacy, the Medical University-Sofia for LC-MS analyses, consultation and advice in the process of identifying the LC-MS spectra. The authors also thank the Research Foundation of Necmettin Erbakan University (BAP) for providing facilities and encouragement (Project No: 161710001). The authors also thank the Serbian Ministry of Education, Science and Technological development for financial support (Grant No. 173032).en_US
dc.identifier.doi10.1039/c6fo01847e
dc.identifier.endpage1165en_US
dc.identifier.issn2042-6496
dc.identifier.issn2042-650X
dc.identifier.issue3en_US
dc.identifier.pmid28174780en_US
dc.identifier.scopus2-s2.0-85016240202en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1152en_US
dc.identifier.urihttps://doi.org/10.1039/c6fo01847e
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12784
dc.identifier.volume8en_US
dc.identifier.wosWOS:000398780200028en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherRoyal Soc Chemistryen_US
dc.relation.ispartofFood & Functionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[Keyword Not Available]en_US
dc.titleShedding light on the biological and chemical fingerprints of three Achillea species (A-biebersteinii, A-millefolium and A-teretifolia)en_US
dc.typeArticleen_US

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