Enhancement of PCL/PLA Electrospun Nanocomposite Fibers Comprising Silver Nanoparticles Encapsulated with Thymus Vulgaris L. Molecules for Antibacterial and Anticancer Activities

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dc.contributor.authorCimen, Cansu Gunes
dc.contributor.authorDundar, Mehmet Akif
dc.contributor.authorKars, Meltem Demirel
dc.contributor.authorAvci, Ahmet
dc.date.accessioned2024-02-23T14:16:37Z
dc.date.available2024-02-23T14:16:37Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractSilver nanoparticles (AgNPs) have been recognized for their outstanding antibacterial activities, which are required for antibacterial coating materials in therapeutic applications. A bacterial resistant electrospun nanofibrous mat made of polycaprolactone (PCL) in combination with polylactide acid (PLA) containing silver nanoparticles encapsulated with Thymus vulgaris L. (thyme) extract (eAgNPs) was fabricated in order to assess the potential of applicability in biomedical applications such as cancer treatment, wound healing, or surgical sutures. In the current study, PCL and PLA used as the basis polymers were blended with biosynthesized eAgNPs, pure AgNPs, and thyme extract (TE) to observe the effects of additives in terms of antibacterial and anticancer activity and morphologic, thermal, mechanical, biocompatibility, and biodegradability properties. The biological characteristics of fabricated electrospun nanofibrous mats were evaluated in vitro. Physicochemical characteristics of the nanofibrous mats were examined by UV-vis spectrophotometry, scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), energy dispersive X-ray (EDX), Fourier-transform infrared spectroscopy (FTIR), mechanical tensile testing, X-ray diffraction (XRD), thermogravimetric examination (TGA), and water contact angles (WCAs). The results showed that a biodegradable nanofiber scaffold with a mean fiber diameter of 280 nm is morphologically homogeneous and highly hydrophobic, has higher tensile strength than PCL/PLA nanocomposite fiber, and is resistant to Escherichia coli and Staphylococcus aureus. The cytotoxic and anticancer properties of nanomaterials were defined using L929 and SK-MEL-30 cells. The developed material inhibited cell proliferation and led to apoptosis of cell lines. It can be suggested that the use of Thymus vulgaris L. extract-encapsulated silver nanoparticle-doped PCL/PLA nanofibers produced by the electrospinning method has the potential for cancer therapy in skin tumor cell lines.en_US
dc.description.sponsorshipNecmettin Erbakan University Scientific Research Projects Coordinatorship (NEU BAP) [211319018]; NEU BAPen_US
dc.description.sponsorshipACKNOWLEDGMENTS This study is supported by Necmettin Erbakan University Scientific Research Projects Coordinatorship (NEU BAP) with project no. 211319018, and we gratefully acknowledge NEU BAP for their financial support.en_US
dc.identifier.doi10.1021/acsbiomaterials.2c00611
dc.identifier.endpage3732en_US
dc.identifier.issn2373-9878
dc.identifier.issue9en_US
dc.identifier.pmid35948432en_US
dc.identifier.scopus2-s2.0-85136252663en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage3717en_US
dc.identifier.urihttps://doi.org/10.1021/acsbiomaterials.2c00611
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12736
dc.identifier.volume8en_US
dc.identifier.wosWOS:000844642300001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Chemical Socen_US
dc.relation.ispartofAcs Biomaterials Science & Engineeringen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnticanceren_US
dc.subjectAntimicrobialen_US
dc.subjectGreen Synthesisen_US
dc.subjectElectrospun Nanocomposite Fiberen_US
dc.subjectThymus Vulgaris Len_US
dc.titleEnhancement of PCL/PLA Electrospun Nanocomposite Fibers Comprising Silver Nanoparticles Encapsulated with Thymus Vulgaris L. Molecules for Antibacterial and Anticancer Activitiesen_US
dc.typeArticleen_US

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