Intratumoral hemorrhage-related differences in the expression of vascular endothelial growth factor, basic fibroblast growth factor and thioredoxin reductase 1 in human glioblastoma

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dc.contributor.authorKaya, Bulent
dc.contributor.authorCicek, Onur
dc.contributor.authorErdi, Fatih
dc.contributor.authorFindik, Siddika
dc.contributor.authorKaratas, Yasar
dc.contributor.authorEsen, Hasan
dc.contributor.authorKeskin, Fatih
dc.date.accessioned2024-02-23T14:35:26Z
dc.date.available2024-02-23T14:35:26Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractThe present study was designed to evaluate the expression of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and thioredoxin reductase 1 (TrxR1) in glioblastoma multiforme (GBM) with and without intratumoral hemorrhage. Surgically resected human GBM samples from 20 patients who underwent surgery at our institute were extracted from the histopathological specimens and divided into two groups. A total of 10 samples from each type of GBM (World Health Organization grade IV, intratumoral hemorrhage-positive or -negative) were included in each group. VEGF, bFGF and TrxR1 expression was analyzed using immunohistochemistry and the results were compared between groups. VEGF and bFGF immunoreactivity was significantly higher in GBMs containing intratumoral hemorrhage. Furthermore, VEGF, bFGF and TrxR1 immunointensity was significantly higher in GBMs containing intratumoral hemorrhage. Thus, the present study demonstrated a higher VEGF, bFGF and TrxR1 expression in GBMs contain intratumoral hemorrhage, indicatiogn a role of VEGF, bFGF and TrxR1 expression in the promotion of tumoral angiogenesis and tumoral growth by complex mechanisms that require further elucidation.en_US
dc.identifier.doi10.3892/mco.2016.974
dc.identifier.endpage346en_US
dc.identifier.issn2049-9450
dc.identifier.issn2049-9469
dc.identifier.issue4en_US
dc.identifier.pmid27699024en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage343en_US
dc.identifier.urihttps://doi.org/10.3892/mco.2016.974
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16031
dc.identifier.volume5en_US
dc.identifier.wosWOS:000453168200002en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpandidos Publ Ltden_US
dc.relation.ispartofMolecular And Clinical Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectThioredoxin Reductase 1en_US
dc.subjectVascular Endothelial Growth Factoren_US
dc.subjectBasic Fibroblast Growth Factoren_US
dc.subjectGlioblastoma Multiformeen_US
dc.subjectIntratumoralen_US
dc.subjectHemorrhageen_US
dc.titleIntratumoral hemorrhage-related differences in the expression of vascular endothelial growth factor, basic fibroblast growth factor and thioredoxin reductase 1 in human glioblastomaen_US
dc.typeArticleen_US

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