Lack of Association of 1513 A/C Polymorphism in P2X7 Gene with Susceptibility to 7 Pulmonary and Extrapulmonary Tuberculosis

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dc.contributor.authorOzdemir, Fethi Ahmet
dc.contributor.authorErol, Deniz
dc.contributor.authorKonar, Vahit
dc.contributor.authorYuce, Hueyin
dc.contributor.authorSenli, Ebru Kara
dc.contributor.authorBulut, Funda
dc.contributor.authorDeveci, Figen
dc.date.accessioned2024-02-23T14:41:47Z
dc.date.available2024-02-23T14:41:47Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractIntroduction: Tuberculosis, is one of the a leading causes of death worldwide, is characterized by different clinical forms including: latent, localized pulmonary infection and extrapulmonary tuberculosis. Candidate gene association studies have implicated common polymophisms in genes that may influence the development of tuberculosis. This study, aimed to elucidate the role of P2X(7) gene in 1513A/C polymorphism the etiopathogenesis of tuberculosis. Materials and Methods: The study included 160 patients with tuberculosis (71 pulmonary and 89 extrapulmonary tuberculosis) and 160 healthy controls. Genomic DNA was isolated and 1513A/C polymorphism in P2X(7) gene was genotyped by PCR-RFLP method. Results: Frequency of P2X(7) AA genotype was 47.5% in controls and 56.87% in patients, AC frequency was 39.37% controls and 32.5% in patients, CC genotype was 13.12% in controls and 10.62% in patients. No significant difference in allele and genotype frequencies (1513A/C polymorphism) between tuberculosis patients and controls was found. Conclusion: The results suggest that 1513A/C polymorphism of P2X(7) gene is not associated with pulmonary and extrapulmonary tuberculosis in the Eastern Turkey.en_US
dc.description.sponsorshipScientific Research Projects Unit (FUBAP) of the Firat University [FF.10.01]en_US
dc.description.sponsorshipThis study was sponsored by Scientific Research Projects Unit (FUBAP) of the Firat University (Project no: FF.10.01).en_US
dc.identifier.doi10.5578/tt.4740
dc.identifier.endpage11en_US
dc.identifier.issn0494-1373
dc.identifier.issue1en_US
dc.identifier.pmid24814072en_US
dc.identifier.scopus2-s2.0-84899764831en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage7en_US
dc.identifier.urihttps://doi.org/10.5578/tt.4740
dc.identifier.urihttps://hdl.handle.net/20.500.12452/17010
dc.identifier.volume62en_US
dc.identifier.wosWOS:000421337600002en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Assoc Tuberculosis & Thoraxen_US
dc.relation.ispartofTuberkuloz Ve Torak-Tuberculosis And Thoraxen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTuberculosisen_US
dc.subjectP2x(7)en_US
dc.subjectPolymorphismen_US
dc.titleLack of Association of 1513 A/C Polymorphism in P2X7 Gene with Susceptibility to 7 Pulmonary and Extrapulmonary Tuberculosisen_US
dc.typeArticleen_US

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