Effects of curcumin on methyl methanesulfonate damage to mouse kidney

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dc.contributor.authorCuce, G.
dc.contributor.authorCetinkaya, S.
dc.contributor.authorIsitez, N.
dc.contributor.authorKuccukturk, S.
dc.contributor.authorSozen, M. E.
dc.contributor.authorKalkan, S.
dc.contributor.authorCigerci, I. H.
dc.date.accessioned2024-02-23T14:34:38Z
dc.date.available2024-02-23T14:34:38Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractMethylmethane sulfonate (MMS) is an alkylating agent that may react with DNA and damage it. We investigated histological changes and apoptosis caused by MMS and the effects of curcumin on MMS treated mouse kidneys. Twenty-four mice were divided into four equal groups: controls injected with saline, a group injected with 40 mg/kg MMS, a group injected with 40 mg/kg MMS and given 100 mg/kg curcumin by gavage, and a group given 100 mg/kg curcumin by gavage. MMS caused congestion and vacuole formation, and elevated the apoptotic index significantly, but had no other effect on kidney tissue. Curcumin improved the congestion and vacuole formation caused by MMS and decreased the apoptotic index. Curcumin administered with MMS appears to decrease the deleterious effects of MMS on the kidney.en_US
dc.identifier.doi10.3109/10520295.2015.1099737
dc.identifier.endpage127en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue2en_US
dc.identifier.pmid26529305en_US
dc.identifier.scopus2-s2.0-84955380189en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage122en_US
dc.identifier.urihttps://doi.org/10.3109/10520295.2015.1099737
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15676
dc.identifier.volume91en_US
dc.identifier.wosWOS:000368552800007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCurcuminen_US
dc.subjectHistopathologyen_US
dc.subjectKidneyen_US
dc.subjectMethylmethane Sulfonateen_US
dc.subjectTunelen_US
dc.titleEffects of curcumin on methyl methanesulfonate damage to mouse kidneyen_US
dc.typeArticleen_US

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