The XRCC1 and TP53 gene polymorphisms are associated with advanced-stage disease and early distant metastasis at diagnosis in non-small cell lung cancer

Basit Öğe Kaydı
dc.contributor.authorKaraagac, Mustafa
dc.contributor.authorGeredeli, Caglayan
dc.contributor.authorYildirim, Mahmut Selman
dc.contributor.authorAltinok, Tamer
dc.contributor.authorDede, Isa
dc.contributor.authorInal, Ali
dc.contributor.authorZamani, Ayse Guel
dc.date.accessioned2024-02-23T14:37:53Z
dc.date.available2024-02-23T14:37:53Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractBackground: Studies on single nucleotide polymorphisms (SNPs) in non-small cell lung cancer (NSCLC) suggest that DNA repair capacity may have prognostic implications for disease recurrence and survival. However, there is no study investigating the relationship between SNPs and the risk of metastasis at the time of initial diagnosis in patients with NSCLC. Objective: This study aimed to investigate the potential predictive value of SNPs in detecting the risk of metastasis at the time of initial diagnosis and poor prognosis in patients with NSCLC. Material and Methods: In this prospective cohort study, we evaluated 275 patients with NSCLC. Analysis of SNPs from peripheral blood cells was performed by a polymerase chain reaction. Excision repair cross-complementing group 1 (ERCC1)- Asn118Asn, excision repair cross-complementing group 2 (ERCC2)-Lys751Gln, X-ray repair cross-complementing group 1 (XRCC1)-Arg399Gln, and tumor protein 53 (TP53)-Arg72Pro polymorphisms were evaluated in conjunction with the development of metastasis. Results: The ERCC1 normal genotype, ERCC2 heterozygote genotype, XRCC1 normal genotype, and TP53 normal genotype were associated with a higher stage and more advanced-stage disease at the time of initial diagnosis (P = 0.027, 0.005, <0.001, and 0.006, respectively). Also, XRCC1 normal genotype and TP53 normal genotype were associated with the risk of metastasis at the time of initial diagnosis (P = <0.001 and 0.002, respectively). Moreover, the XRCC1 normal genotype was associated with the risk of brain metastasis at the time of initial diagnosis (P = 0.031). Conclusions: We showed that SNPs are related to a higher stage and more advanced-stage disease at the time of initial diagnosis in patients with NSCLC, and XRCC1 and TP53 gene polymorphisms are associated with the risk of metastasis. These results may contribute to the identification of high-risk groups and may help to earlier diagnosis and treatment in patients with NSCLC.en_US
dc.description.sponsorshipScientific Research Project of The University [11102028]en_US
dc.description.sponsorshipThis study was performed with the financial support of the Scientific Research Project of The University [Project no.: 11102028].en_US
dc.identifier.doi10.4103/jcrt.jcrt_1657_21
dc.identifier.endpage1254en_US
dc.identifier.issn0973-1482
dc.identifier.issn1998-4138
dc.identifier.issue5en_US
dc.identifier.pmid37787291en_US
dc.identifier.scopus2-s2.0-85173661476en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1248en_US
dc.identifier.urihttps://doi.org/10.4103/jcrt.jcrt_1657_21
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16252
dc.identifier.volume19en_US
dc.identifier.wosWOS:001099042700024en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofJournal Of Cancer Research And Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBiomarkeren_US
dc.subjectMetastasisen_US
dc.subjectNon-Small Cell Lung Canceren_US
dc.subjectSingle Nucleotide Polymorphismen_US
dc.subjectStageen_US
dc.titleThe XRCC1 and TP53 gene polymorphisms are associated with advanced-stage disease and early distant metastasis at diagnosis in non-small cell lung canceren_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu