Increased serum brain-derived neurotrophic factor and adrenocorticotropic hormone levels are associated with obsessive compulsive disorder in medication-free children

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dc.contributor.authorBilgic, Ayhan
dc.contributor.authorSertdemir, Merve
dc.contributor.authorKilinc, Ibrahim
dc.contributor.authorAkca, Omer Faruk
dc.date.accessioned2024-02-23T13:55:54Z
dc.date.available2024-02-23T13:55:54Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractThis study aimed to investigate serum levels of neurotrophins, including brain-derived neurotrophic factor (BDNF), glial-derived neurotrophic factor (GDNF), nerve growth factor (NGF) and neurotrophin-3 (NTF3), and hypothalamic-pituitary-adrenal axis (HPA) members including adrenocorticotropic hormone (ACTH) and cortisol in children with obsessive-compulsive disorder (OCD). The possible relationships between serum neurotrophins and HPA axis members were also addressed. A total of 60 medication-free children with OCD and 57 controls aged 8-18 years were enrolled in this study. The severity of OCD symptoms was determined by the Children's Yale-Brown Obsessive Compulsive Scale. The severity of anxiety and depression symptoms were assessed by self-report inventories. The serum levels of neurotrophins, ACTH, and cortisol were measured using enzyme-linked immunosorbent assay kits. Serum BDNF levels were significantly higher in the OCD group than in the control group for either sex and for the whole sample. Compared to controls, serum ACTH levels were significantly higher in the OCD group for the whole sample. An analysis of covariance was also conducted for the whole sample and indicated that, while controlling the potential confounders, including body-mass index percentile, age, sex, and the severity of depression and anxiety, the results did not change. Strong negative correlations between BDNF, NGF and NTF3, and HPA axis members were determined in the patient group for either sex and for the whole sample. These findings suggest that dysregulations of BDNF and ACTH may be associated with childhood OCD. Furthermore, there may be inverse relationships between certain neurotrophins and HPA axis members in these patients.en_US
dc.description.sponsorshipScientific Research Project Coordination Unit of Necmettin Erbakan University [191218008]en_US
dc.description.sponsorshipFunding for this study was provided by a grant from the Scientific Research Project Coordination Unit of Necmettin Erbakan University (Project Number: 191218008).en_US
dc.identifier.doi10.1007/s00787-020-01690-6
dc.identifier.endpage335en_US
dc.identifier.issn1018-8827
dc.identifier.issn1435-165X
dc.identifier.issue2en_US
dc.identifier.pmid33389158en_US
dc.identifier.scopus2-s2.0-85098523076en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage325en_US
dc.identifier.urihttps://doi.org/10.1007/s00787-020-01690-6
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11007
dc.identifier.volume31en_US
dc.identifier.wosWOS:000604218200002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Child & Adolescent Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectObsessive- Compulsive Disorderen_US
dc.subjectNeurotrophinsen_US
dc.subjectAdrenocorticotropic Hormoneen_US
dc.subjectCortisolen_US
dc.subjectChildrenen_US
dc.titleIncreased serum brain-derived neurotrophic factor and adrenocorticotropic hormone levels are associated with obsessive compulsive disorder in medication-free childrenen_US
dc.typeArticleen_US

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