The effects of chronic restraint stress on empathy-like behaviour in rats

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dc.contributor.authorSen, Aysu
dc.contributor.authorKara, Ali Yucel
dc.contributor.authorKoyu, Ahmet
dc.contributor.authorSimsek, Fatma
dc.contributor.authorKizildag, Servet
dc.contributor.authorUysal, Nazan
dc.date.accessioned2024-02-23T14:13:19Z
dc.date.available2024-02-23T14:13:19Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractIt is clearly known that psychological stress is an important threat to health in today's modern societies. Recent studies have shown that acute stress causes an increase in positive social behaviours such as prosocial behaviour and devotion which are components of empathic behaviour. Neuropsychiatric manifestations such as anxiety and depression may affect empathic behaviour. The aim of this study was to investigate the effects of chronic restraint stress on empathy-like behaviour and the histopathological changes in the amygdala, prefrontal cortex in the adrenal glands and thymus, as well as the neurochemical pathways associated with empathy, oxytocin and vasopressin. The chronic stress group was subjected to restraint stress daily for 14 days after all subjects were trained to rescue its stressed cagemate using empathy test equipment for 12 days. It was observed that chronic restraint stress had no effect on empathy-like behaviour in rats. Vasopressin levels in amygdala was increased in chronic stress group compared to control group. Anxiety and depression indicators did not change in both groups. In the open field test, control group spent more time in thigmo zone compared to chronic stress group. Adrenal glands relative weights and apoptotic cell ratios were significantly higher in the chronic stress group compared to the control group (expectedly). Although there was no significant difference in behavioral tests, histopathological changes were detected. In subsequent studies, it is appropriate to examine the effects of different types of stress applications, gender-related changes, and other neurochemical pathways associated with stress and empathy.en_US
dc.description.sponsorshipIzmir Katip Celebi University, Scientific Research Foundation [2018-TDU-TIPF-0047]en_US
dc.description.sponsorshipChemical agents and consumables used in this study were supplied from the project funded by Izmir Katip Celebi University, Scientific Research Foundation with project number 2018-TDU-TIPF-0047.en_US
dc.identifier.doi10.1016/j.neulet.2021.136255
dc.identifier.issn0304-3940
dc.identifier.issn1872-7972
dc.identifier.pmid34537317en_US
dc.identifier.scopus2-s2.0-85115742850en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.neulet.2021.136255
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12389
dc.identifier.volume765en_US
dc.identifier.wosWOS:000703199500002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofNeuroscience Lettersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEmpathyen_US
dc.subjectChronic Restraint Stressen_US
dc.subjectOxytocinen_US
dc.subjectVasopressinen_US
dc.subjectAmygdalaen_US
dc.subjectPrefrontal Cortexen_US
dc.titleThe effects of chronic restraint stress on empathy-like behaviour in ratsen_US
dc.typeArticleen_US

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