Effects of Combined Sertraline and Magnesium in Rat Atrium

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dc.contributor.authorFidan, Esra
dc.contributor.authorGormus, Z. Isik Solak
dc.contributor.authorKilinc, Ibrahim
dc.contributor.authorIyisoy, Mehmet Sinan
dc.contributor.authorGormus, Niyazi
dc.date.accessioned2024-02-23T13:59:43Z
dc.date.available2024-02-23T13:59:43Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractThe objective of this study is to determine the synergistic effects of an antioxidant ion Mg+2, combined with selective serotonin reuptake inhibitor sertraline, in treatment or prevention of major depression and regulation of inotropic effect in the early postoperative period. Adult male 40 Wistar albino rats were randomly divided into 6 groups. Three to 4-mm long atrium strips were placed in organ bath, tension was adjusted to 2 g. Isometric contractions were induced with 10(-3) M adrenaline. Group 1 was the control group, cumulative sertraline was given to group 2, cumulative MgSO4 to group 3, combined cumulative sertraline and MgSO4 to group 4, intraperitoneal sertraline injection for 29 days to group 5, and intraperitoneal MgSO4 injection for 14 days to group 6. Changes in weight, tensions, bleeding/clotting time, and biochemical findings were evaluated statistically. Isometric tension relationship between groups 1 and 3 was statistically significant after 4 mmol/L MgSO4 (p < 0.05). A rapid inhibition of contraction was observed in group 4. Inhibition of spontaneous contractions of groups 5 and 6 was found to be statistically significant at close values, p < 0.05. When blood clotting times were compared, a statistically marked decrease was found in group 6, p < 0.05. Compared to control group, there was a significant decrease in blood lipids in group 4. While LDH and CK-MB increased from plasma enzymes in groups 5 and 6, no significant change was observed in NT-proBNP. Combined treatment of high dose MgSO4 with antidepressants for pre or post-operative depression may cause fatal risks. Shortening clotting time may increase the risk of embolism and stroke. In order to reduce the risk of post-operative depression preoperatively, care should be taken when using magnesium combined with antidepressants and more studies are needed to be considered.en_US
dc.description.sponsorshipScientific Investigations Projects Coordinatorship of Necmettin Erbakan University [181318014]en_US
dc.description.sponsorshipThe study was supported by the Scientific Investigations Projects Coordinatorship of Necmettin Erbakan University (SIPC Project Number: 181318014).en_US
dc.identifier.doi10.1007/s12011-021-02669-3
dc.identifier.endpage660en_US
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue2en_US
dc.identifier.pmid33774751en_US
dc.identifier.scopus2-s2.0-85103369538en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage652en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-021-02669-3
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11294
dc.identifier.volume200en_US
dc.identifier.wosWOS:000634302000001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofBiological Trace Element Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRat Atriumen_US
dc.subjectIsolated Organ Bathen_US
dc.subjectMagnesium Sulfateen_US
dc.subjectSertralineen_US
dc.subjectContractilityen_US
dc.titleEffects of Combined Sertraline and Magnesium in Rat Atriumen_US
dc.typeArticleen_US

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